RESUMO
PURPOSE: To evaluate if parabulbar triamcinolone reduces orbital swelling in patients with Graves ophthalmopathy. METHODS: This is a prospective study of a series of patients with active and moderate Graves ophthalmopathy. Short tau inversion recovery magnetic resonance was used to evaluate the intensity of the extraocular rectus muscles and orbital fat, before and after the treatment with parabulbar triamcinolone. RESULTS: The signal intensity ratio of the sum of the OD rectus muscles was 3.67 before treatment (95% CI, 3.26-4.09) and 2.83 after treatment (95% CI, 2.63-3.03) (p < 0.001), and of the muscles of the left orbit, 3.94 before treatment (95% CI, 3.50-4.38) and 2.85 after treatment (95% CI, 2.56-3.14) (p < 0.001). The signal intensity ratio of the fat decreased from 2.95 (95% CI, 2.69-3.21) to 2.33 (95% CI, 2.07-2.58) (p < 0.001). After treatment, there were no local or systemic complications. CONCLUSION: The use of parabulbar triamcinolone reduces orbital inflammation of patients with active and moderate Graves ophthalmopathy.
Assuntos
Oftalmopatia de Graves/tratamento farmacológico , Imageamento por Ressonância Magnética/métodos , Órbita/diagnóstico por imagem , Triancinolona/administração & dosagem , Adolescente , Adulto , Feminino , Seguimentos , Glucocorticoides/administração & dosagem , Oftalmopatia de Graves/diagnóstico , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento , Adulto JovemRESUMO
PURPOSE: The aim of this study was to determine if patients with strabismic amblyopia could have increased occipital visual cortex activation with monocular stimulation of the sound fixing eye, rather than with simultaneous stimulation of both eyes. METHODS: A prospective study was performed including 12 patients with strabismus and amblyopia, who were evaluated using functional MRI with visual stimulation paradigms. The measurements were made in the occipital visual cortex, assessing the response to the binocular and monocular stimulation. RESULTS: 12 out of 12 patients showed an increased cortical response of the healthy eye in comparison to the amblyopic one. Nine of the 12 patients showed larger cortical activation with visual stimulation of the healthy eye compared to the binocular condition analysis. Three out of the 12 cases had a greater activation area when the stimulation was binocular rather than monocular, 2 of whom had a relatively small angle of strabismus. CONCLUSIONS: Patients with amblyopia and strabismus could see better with only one eye instead of both eyes. This could be related to inhibition of the binocular function of the brain by the misaligned amblyopic eye.
