RESUMO
We report the case of a 66-year-old man with adult-onset seizures and multiple cerebral cavernous malformations who developed numerous eruptive cutaneous angiokeratomas on the legs, scrotum, abdomen, and back as well as lobular and cavernous hemangiomas on the arms. Genetic analysis demonstrated a mutation in the KRIT1, ankyrin repeat containing gene (also known as CCM1).
Assuntos
Angioceratoma/diagnóstico , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico , Hemangioma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Angioceratoma/genética , Angioceratoma/patologia , Hemangioma/genética , Hemangioma/patologia , Hemangioma Cavernoso do Sistema Nervoso Central/genética , Hemangioma Cavernoso do Sistema Nervoso Central/patologia , Humanos , Proteína KRIT1 , Masculino , Proteínas Associadas aos Microtúbulos/genética , Mutação , Proteínas Proto-Oncogênicas/genética , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologiaRESUMO
Interferon/ribavirin combination therapy is the treatment of choice for chronic hepatitis C virus (HCV) infection. Cutaneous reactions to inferferon therapy, both local and distant from the injection site, are not uncommon. Eczematous and lichenoid reactions are most commonly reported. Interferon therapy has also been associated with the occurrence or worsening of a number of dermatologic disorders. We report the case of a 54-year-old man undergoing treatment with interferon/ribavirin combination therapy for hepatitis C who developed a multiple fixed drug eruption associated with interferon injections. To our knowledge, this is the first known reported case of a multiple fixed drug reaction triggered by interferon.
