[Perfusion protection of ischemic liver using perfluorocarbon emulsion]. / Perfuzionnaia zashchita ishemizirovannoi pecheni s ispol'zovaniem perftorugliarodnoi émul'sii.

Several concentrations of Fluorocarbon emulsion as means for anti-ischemic protection of the liver were studied in experiments on 47 rabbits with hypothermic perfusion of isolated liver exposed to 90 minute ischaemia. the best concentration of Fluorocarbon emulsion for perfusion of isolated liver was 12%.

[Anti-ischemic protection of the liver using perfluorocarbon emulsion]. / Protivoishemicheskaia zashchita pecheni s primenenium perftoruglerodnoi émul'sii.

Anti-ischemic effectiveness of a Soviet perfluorocarbon emulsion (PFE) was studied in 43 experiments on rabbits with 90-min constriction of the hepatoduodenal ligament and under hypothermic perfusion of the liver during ischemia in the open contour. It has been established that PFE perfusion to a great extent promotes the retention of the ischemized liver function.

[Hematopoietic study of rats in experiments with exchange blood replacement by an emulsion of perfluorotributylamine]. / Izuchenie krovetvoreniia u krys v opytakh s obmennym zameshcheniem krovi émul'siei perftortributilamina.

In experiments on nonanesthetized rats blood was substituted with perfluorotributyl emulsion (PFTBA). The mean volume of transfused PFTBA was 10 ml/100 g of body weight. During the period of blood replacement and the following 5 days the rats were kept in an atmosphere with increased oxygen content, and then they were placed under normal atmospheric conditions. The influence of PFTBA solution on hemopoiesis was studied in these experiments. A marked erythropoiesis activation in the bone marrow combined with expressed peripheral blood reticulocytosis was observed 6 days after the exchange blood substitution. Hemoglobin content decreased to 8.2 g% mature and immature white cell count rose; immature erythropoiesis cells were found: polychromatophilic erythro- and normoblasts (4.2% on the average). By the 13th day there was complete normalization of hemopoiesis which lasted 12 months without any significant deviations. Basing upon the results obtained it may be concluded that the PFTBA emulsion under study produces no negative effect on the animal hemopoiesis, and does not disturb the normal regulation process under conditions of the experiment conducted.