[Sulindac in the treatment of soft tissue rheumatism (periarthropathy of the hip and shoulder (author's transl)]. / Sulindac in der Behandlung des Weichteilrheumatismus (Periarthropathia humeri et coxae).

Sulindac (Clinoril) was tested in an open clinical-therapeutical study with regard to its analgesic effect and the improvement of function in 20 patients of both sexes suffering from periarthropathy of the hip or shoulder. The treatment lasted 4 weeks. The therapeutic effect was judged on the basis of the influence on the spontaneous pain and on the pain by pressure, on the functional improvement and on the daily habits of the patients. It was noted, that there was a lasting improvement due to the analgesic effect already in the first week of therapy and an improvement of function in the second week of therapy in the majority of the cases. Sulindac was well tolerated. Laboratory findings in the beginning and at the end of the four weeks treatment period revealed no toxic effects on organs, particularly on hematopoietic system.

A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.

In this controlled, single-blind parallel group study, the effect of ibuprofen 1200 mg daily was compared with diclofenac 75 mg daily. Thirty patients entered the study, randomized into two groups, each group receiving one tablet three times daily for two weeks. A one-week wash-out period (i.e. a drug-free period during which only physiotherapy was given), preceded and followed the treatment on active drug. Assessments were made by the same clinician throughout who was unaware of the treatment of individual patients. Statistically significant improvement was shown by patients receiving ibuprofen for the degree of pain relief at rest and improvement was also shown for the degree of pain at rest and during exercise, for pain relief during exercise and for spinal flexion. Patients who received diclofenac showed statistically significant improvement for forward flexion, together with improvement for the degree of pain on exercise. Side-effects were very few.