[Early hemostasis after coronary therapeutic interventions by using a collagen plug]. / Frühzeitige Blutstillung nach koronartherapeutischen Eingriffen durch Anwendung von Kollagenplugs.

Significant bleeding at the puncture site is one of the most important problems in the care of patients undergoing interventional coronary procedures like PTCA, rotablation, laser angioplasty or stent implantation. This is due to systemic application of heparin, acetylic salicic acid and, in stent patients, even additional coumadine. Furthermore, the interventional systems implement catheter systems with a large inner and outer lumen leading to increased vessel trauma. To decrease the risk of bleeding and to reduce the time of pressure dressing and bed rest, a bovine collagen plug (VasoSeal) was used in 600 consecutive patients undergoing one of the above-mentioned interventional procedures. In the majority of patients (pts.) (474/600 = 79%) either no (404 pts.) or minimal (70 pts.) bleeding occurred. Bed rest could be reduced from more than 24 h to 6-12 h. In 65/600 pts. (11%) significant bleeding developed which could be controlled by compression. Bed rest in these patients was 13-20 h. Larger bleedings or complications occurred in 61/600 pts. (10.2%) and could be controlled conservatively in all but eight patients. One patient (0.2%) had a narrowing of the artery at the puncture site after the procedure, probably due to intraarterial plug application. In another patient (0.2%) embolization of the plug into the popliteal artery occurred which could be treated by embolectomy using a Fogarty-catheter. Arteriovenous fistulae or aneurysms developed in 8/600 pts. (1.3%) but these are no specific complications of the hemostatic device. The plug could not be placed in 13/600 pts. (2%), mainly in the beginning of the study.(ABSTRACT TRUNCATED AT 250 WORDS)