[Two stages of contact interaction of liposomes with bimolecular lipid membranes]. / Dve stadii kontaktnogo vzaimodeistviia liposom i biomolekuliarnykh lipidnykh membran.

Interaction of liposomes with BLM is confirmed to consist of two stages. The first stage is a semi-fusion of liposomes with BLM. On this stage the bilayer in a contact area is formed of one liposome monolayer and another one of BLM. The second stage is inclusion of liposome bilayers into BLM; it occurs some tens of minutes after the first one. It occurs either by fusion or incorporation. The fusion to incorporation ratio increases with temperature. Liposomes are incorporated in BLM asymmetrically: the contact area of the liposome bilayer is always smaller than the free one.

[Relationship between ion channel properties and the structure of the lactone ring of polyene antibiotic molecules]. / Zavisimost' svoistv ionnykh kanalov ot struktury laktonnogo kol'tsa molekul polienovykh antibiotikov.

Properties of ionic channels created by amphoterecin B, nystatine and mycoheptin in phospholipid--cholesterol bilayer have been compared. Ionic conductivity and selectivity of channels as well as the frequency of transitions between an open state and a closed one depend on lacton ring structure. Appearance of one more carbonyl group in mycoheptin molecule leads to a decrease of channel anion permeability. Any pair of these antibiotics being added into different aqueous solutions create combined channels. These data confirm hypothesis that polyene antibiotics create channels of two half-pores formed in different monolayers of the membrane.