A Fusion Algorithm for Saccade Eye Movement Enhancement With EOG and Lumped-Element Models.

Electrooculography (EOG) can be used to measure eye movements while the eyelids are open or closed and to assist in the diagnosis of certain eye diseases. However, challenges in biosignal acquisition and processing lead to limited accuracy, limited resolution (both temporal and spatial), as well as difficulties in reducing noise and detecting artifacts. Methods such as finite impulse response, wavelet transforms, and averaging filters have been used to denoise and enhance EOG measurements. However, these filters are not specifically designed to detect saccades, and so key features (e.g., saccade amplitude) can be over-filtered and distorted as a consequence of the filtering process. Here we present a model-based fusion technique to enhance saccade features within noisy and raw EOG signals. Specifically, we focus on Westheimer (WH) and linear reciprocal (LR) eye models with a Kalman filter. EOG signals were measured using OpenBCI's Cyton Board (at 250 Hz), and these measurements were compared with a state-of-the-art EyeLink 1000 (EL; 250 Hz) eye tracker. On average, the LR model-based KF produced a 47% improvement of measurement accuracy over the bandpass filters. Thus, we conclude that our LR model-based KF outperforms standard bandpass filtering techniques in reducing noise, eliminating artifacts, and restoring missing features of saccade signatures present within EOG signals.

A Geometrical Approach to Human Saccade Simulation.

Modeling and simulation of human eye movement have a wide range of applications in many domains. Various attempts have been made to model and simulate eye movements in a physically accurate manner. All the existing models show limitations and problems in simulating secondary and tertiary eye movements. Recent investigation of pulley models (passive and active hypotheses) in representing human eye motion has recognized mathematical complexity in modeling eye behavior. Sophisticated techniques of modeling are required to investigate eye movements. This paper presents a procedure for eye movement simulation through geometrical modeling (an OpenSim script with its recent MATLAB binding) for binocular vision. First order neural dynamics with Millard's muscle model are used to actuate six Extra Ocular Muscles (EOMs). Pulse-step inputs are used to generate the muscle forces around the eye globe. The implemented model is successful in simulating horizontal and vertical movements of the human eye with respect to the prescribed activation. The developed technique is evaluated using responses from lumped parameter models and EOG recordings.

The complete genome of a baculovirus isolated from an insect of medical interest: Lonomia obliqua (Lepidoptera: Saturniidae).

Lonomia obliqua (Lepidoptera: Saturniidae) is a species of medical importance due to the severity of reactions caused by accidental contact with the caterpillar bristles. Several natural pathogens have been identified in L. obliqua, and among them the baculovirus Lonomia obliqua multiple nucleopolyhedrovirus (LoobMNPV). The complete genome of LoobMNPV was sequenced and shown to have 120,022 bp long with 134 putative open reading frames (ORFs). Phylogenetic analysis of the LoobMNPV genome showed that it belongs to Alphabaculovirus group I (lepidopteran-infective NPV). A total of 12 unique ORFs were identified with no homologs in other sequenced baculovirus genomes. One of these, the predicted protein encoded by loob035, showed significant identity to an eukaryotic transcription terminator factor (TTF2) from the Lepidoptera Danaus plexippus, suggesting an independent acquisition through horizontal gene transfer. Homologs of cathepsin and chitinase genes, which are involved in host integument liquefaction and viral spread, were not found in this genome. As L. obliqua presents a gregarious behavior during the larvae stage the impact of this deletion might be neglectable.

Fistula pieloduodenal - relato de um caso. / Pyeloduodenal fistula - report of a case

Os autores apresentam um caso de fistula pieloduodenal de origem traumatica discutindo suas etiologias e tratamento