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Hydrogels have attracted great interest in the biomedical applications field in recent years [...].
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Background and Objectives: Particulate Matter (PM), particles of variable but small diameter can penetrate the respiratory system via inhalation, causing respiratory and/or cardiovascular diseases. This study aims to evaluate the association of environmental particulate matter (PM2.5) and black carbon (BC) with respiratory health in users of different transport modes in four roads in Bogotá. Materials and Methods: this was a mixed-method study (including a cross sectional study and a qualitative description of the air quality perception), in 300 healthy participants, based on an exploratory sequential design. The respiratory effect was measured comparing the changes between pre- and post-spirometry. The PM2.5 and black carbon (BC) concentrations were measured using portable devices. Inhaled doses were also calculated for each participant according to the mode and route. Perception was approached through semi-structured interviews. The analysis included multivariate models and concurrent triangulation. Results: The concentration of matter and black carbon were greater in bus users (median 50.67 µg m-3; interquartile range (-IR): 306.7). We found greater inhaled dosages of air pollutants among bike users (16.41 µg m-3). We did not find changes in the spirometry parameter associated with air pollutants or transport modes. The participants reported a major sensory influence at the visual and olfactory level as perception of bad air quality. Conclusions: We observed greater inhaled doses among active transport users. Nevertheless, no pathological changes were identified in the spirometry parameters. People's perceptions are a preponderant element in the assessment of air quality.
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Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/efeitos adversos , Carbono , Colômbia , Estudos Transversais , Exposição Ambiental/efeitos adversos , Humanos , Material Particulado/efeitos adversosRESUMO
Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechanical properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coefficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material's tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.
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RESUMEN Objetivo El manejo del dolor crónico no oncológico con analgésicos opioides ha sido de importancia para el control de los síntomas y el restablecimiento de la actividad. Sin embargo, el riesgo de adicción asociado a estos medicamentos es ampliamente conocido y evaluado. Este estudio evalúa el riesgo de adicción que presentaban los pacientes con manejo de tramadol describiendo los factores más frecuentes en la muestra estudiada frente a lo reportado en la literatura. Métodos Una muestra de 76 pacientes de una clínica de dolor que están en manejo con tramadol se les administra un cuestionario con características demográficas y con la escala Opioid Risk Tool para el riesgo de adicción. Resultados El 57,89% de los sujetos fueron mujeres; el 55,20% se encontraba entre los 29 y 59 años. El riesgo de adicción moderado se encontró en el 9,09% de las mujeres y en el 37,05% de los hombres. La inclusión de otras enfermedades como ansiedad y trastorno de estrés postraumático aumenta el riesgo de adicción a severo en 6,06% de los hombres. Conclusiones La valoración del riesgo de adicción a opioides debe tener en cuenta los factores encontrados en la población colombiana.
ABSTRACT Objective The management of chronic non-cancer pain with opioid analgesics has been important for the control of symptoms and the restoration of activity, however, the risk of addiction associated with these drugs is widely known. This study evaluates the risk of addiction presented by patients with tramadol treatment, describing the most frequent factors in the sample studied compared to what was reported in the literature. Methods A sample of 76 patients from a pain clinic who are being managed with tramadol are administered a questionnaire with demographic characteristics and with the Opioid Risk Tool scale for the risk of addiction. Results 57.89% of the subjects were women, 55.20% were affected between 29 and 59 years. A moderate risk of addiction was found in 9.09% of women and 37.05% of men. The inclusion of other diseases such as anxiety and post-traumatic stress disorder increases the risk of addiction to severe in 6.06% of men. Conclusions The assessment of the risk of addiction to opioids must consider the factors found in the Colombian population.
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Resumen Las tecnologías digitales en salud han permitido que los pacientes estén mejor informados, reducir tiempos y distancias para intervenciones en salud, lo que ha generado un cambio en la relación médico-paciente. El objetivo de este artículo fue explorar la evidencia relacionada con la influencia de WhatsApp en la relación médico-paciente. Por ello, se realizó una rápida revisión de la literatura en cinco bases de datos científicas. Obtuvimos un total de cuatro estudios que completaron los criterios de inclusión para la revisión: un reporte de caso, un estudio de casos y controles y dos estudios observacionales. El 65 % de los estudios incluidos informaron el uso de WhatsApp para la relación médico-paciente. La aplicación WhatsApp puede ser una herramienta útil como canal de comunicación en la relación. Se requiere tener especial cuidado con los aspectos éticos y legales de la comunicación entre profesionales y pacientes.
Abstract Digital technologies in health have allowed patients to be better informed, reduce times and distances for interventions in health, which has generated a change in the doctor-patient relationship. The objective of this article was to explore the evidence related to the influence of WhatsApp among the doctor-patient relationship. Therefore, a rapid review of the literature was carried out in five scientific databases. We obtained a total of four studies who completed the inclusion criteria for the review: a report case study, a case-control study, and two descriptive studies. 65% of the included studies reported the usage of WhatsApp for medical - patient relationship. WhatsApp application can be a useful tool as a communication channel in the relationship. Is required to take special care with ethical and legal aspects of communication between professionals and patients.
