Características Clínico-Patológicas e Tratamento do Ameloblastoma Unicístico: Relato de Caso / Clinical Pathologic Characteristics and Unicystic Ameloblastoma Treatment: Case Report

O ameloblastoma é um tumor odontogênico benigno de origem epitelial, localmente invasivo, de curso lento e que apresenta consideráveis taxas de recidivas. É considerado o tumor odontogênico benigno mais relevante clinicamente, sendo atualmente classificado como "ameloblastoma", "ameloblastoma unicístico", "ameloblastoma periférico ou extraósseo" e "ameloblastoma metastatizante". A variante unicística é a segunda mais prevalente, respondendo por aproximadamente 15% de todos os ameloblastomas, mostrando características singulares especialmente em pacientes mais jovens. Este trabalho tem por finalidade aclarar as características desta variante do ameloblastoma a partir do relato de caso do atendimento de um paciente adulto jovem acometido pelo tumor na mandíbula, abordando os aspectos clínicos, imaginológicos, histopatológicos, terapêuticos e prognósticos envolvidos. Neste caso clínico, o tratamento de escolha para o ameloblastoma unicístico foi, inicialmente, a marsupialização da lesão e posteriormente a enucleação com ostectomia periférica e exodontia dos dentes envolvidos. Esta opção de tratamento demonstrou bons resultados, diminuindo os danos ao paciente quando bem indicada, para isso é essencial um diagnóstico precoce e assertivo associando características clínicas e histopatológicas. O paciente segue em proservação cautelosa, visto que o padrão de proliferação do tipo mural requer uma maior atenção dada a sua maior possibilidade de recidiva

The ameloblastoma is an epithelial benign odontogenic tumor which is locally invasive, slow-growing and presents considerable recidive rates. It is considered the most clinically relevant benign odontogenic tumor, currently being classified as "ameloblastoma", "unicystic ameloblastoma", "peripheral or extraosseous ameloblastoma" and "metastatic ameloblastoma". Unicystic type is the second most prevalent ameloblastoma, occurring in approximately 15% of all ameloblastomas, showing specific characteristics, especially in younger patients. The aim of this study is to clarify the characteristics of this type of ameloblastoma, presenting the case report of a young patient affected by the tumor in the jaw, highlighting clinical, imaginological, histopathological, therapeutic and prognostic aspects involved. In this case, the chosen treatment was, initially, the marsupialization of the lesion and posteriorly the enucleation with peripheral ostectomy and tooth extraction involved. This treatment option has shown good results, decreasing the patients damage when properly indicated, for this, an early and assertive diagnosis is essential, associating clinical and histopathological characteristics. The patient keeps on careful follow-up, since the proliferation pattern of the mural type requires greater attention given its greater possibility of recidive.

Reproductive toxicity of the hydroethanolic extract of the flowers of Acmella oleracea and spilanthol in zebrafish: In vivo and in silico evaluation.

Hydroethanolic preparations of Acmella oleracea is used in the north of Brazil as a female aphrodisiac. Thus, the objective of this study was to evaluate the action of the hydroethanolic extract of Acmella oleracea (EHFAo) flowers (21.873 and 44.457 mg/kg) and spilanthol (3 mg/kg) administered orally on reproductive performance and effects on the embryonic development of zebrafish F1 generation. It was observed that in the groups in which males and females received EHFAo and spilanthol, the spawning was interrupted, whereas in the groups in which only the females were treated, spawning occurred during the 21 days. Thus, in the histopathological evaluation of the gonads, it was possible to observe that the percentage of mature cells in the spermatozoa and females was significantly reduced. Only the embryo groups in which parental generation was treated with EHFAo showed lethal and teratogenic effects. On the other hand, the parental groups treated with the spilanthol presented only the lethality. Spilanthol and some metabolites showed good oral availability and important toxicological properties. Thus, it is suggested that the treatment of parental generation of zebrafish with EHFAo and spilanthol caused severe changes in the gonads and on fertility. However, on the embryo, the most striking effects in the development were recorded in the groups in which the parental generation was treated with the EHFAo, while the spilanthol influenced the lethality of the embryos.