RESUMO
Background: The use of injectable anesthetics to induce and maintain anesthesia has been the subject of extensive research.Ketamine induces dissociative anesthesia, which is characterized by sensory loss, analgesia and amnesia without loss of consciousness. The levorotatory isomer of ketamine is dextroketamine. Detomidine, a potent myorelaxant that acts as a sedative andanalgesic, is commonly used on horses but rarely tested in dogs. The purpose of this study was to evaluate the cardiorespiratoryand anesthetic effects promoted by a combination of detomidine and dextroketamine applied via continuous intravenous infusionin bitches premedicated with midazolam and morphine.Materials, Methods & Results:Eight bitches treated at the veterinary hospital of the Federal University of Campina Grande werereferred for elective ovariohysterectomy (OHE). The animals were premedicated with 0.3 mg/kg of midazolam and 0.1 mg/kgof morphine intramuscular (IM) followed, after 15 min, with 0.02 mg/kg of detomidine IM. Fifteen min after the administration of detomidine, 3.5 mg/kg of dextroketamine was administered intravenously (IV), followed by continuous IV infusion of14 mg/kg/h of dextroketamine and 30 μg/kg/h of detomidine. Heart rate (HR), respiratory rate (RR), body temperature (BT),mean arterial pressure (MAP), myorelaxation and electrocardiogram were recorded before and 15 min after the administrationof midazolam and morphine (M0 and M1), 15 min after detomidine (M2), immediately after starting the infusion (M3), at 10min intervals up to 60 min (M4, M5, M6, M7, M8 and M9) and 30 min after the end of the infusion (M10). Blood gas variableswere analyzed at M0, M1, M2, M6, M9 and M10. Analgesia was evaluated by measuring cortisol and glucose levels at M0, threemin after dermotomy, three min after clamping the ovarian pedicle, and three min after dermorrhaphy. The quality and durationof recovery were evaluated. HR dropped significantly from...(AU)
Assuntos
Animais , Feminino , Cães , Anestesia Intravenosa/veterinária , Midazolam , Morfina , Agonistas de Receptores Adrenérgicos alfa 2 , Ovariectomia/veterinária , Histerectomia/veterináriaRESUMO
Background: The use of injectable anesthetics to induce and maintain anesthesia has been the subject of extensive research.Ketamine induces dissociative anesthesia, which is characterized by sensory loss, analgesia and amnesia without loss of consciousness. The levorotatory isomer of ketamine is dextroketamine. Detomidine, a potent myorelaxant that acts as a sedative andanalgesic, is commonly used on horses but rarely tested in dogs. The purpose of this study was to evaluate the cardiorespiratoryand anesthetic effects promoted by a combination of detomidine and dextroketamine applied via continuous intravenous infusionin bitches premedicated with midazolam and morphine.Materials, Methods & Results:Eight bitches treated at the veterinary hospital of the Federal University of Campina Grande werereferred for elective ovariohysterectomy (OHE). The animals were premedicated with 0.3 mg/kg of midazolam and 0.1 mg/kgof morphine intramuscular (IM) followed, after 15 min, with 0.02 mg/kg of detomidine IM. Fifteen min after the administration of detomidine, 3.5 mg/kg of dextroketamine was administered intravenously (IV), followed by continuous IV infusion of14 mg/kg/h of dextroketamine and 30 μg/kg/h of detomidine. Heart rate (HR), respiratory rate (RR), body temperature (BT),mean arterial pressure (MAP), myorelaxation and electrocardiogram were recorded before and 15 min after the administrationof midazolam and morphine (M0 and M1), 15 min after detomidine (M2), immediately after starting the infusion (M3), at 10min intervals up to 60 min (M4, M5, M6, M7, M8 and M9) and 30 min after the end of the infusion (M10). Blood gas variableswere analyzed at M0, M1, M2, M6, M9 and M10. Analgesia was evaluated by measuring cortisol and glucose levels at M0, threemin after dermotomy, three min after clamping the ovarian pedicle, and three min after dermorrhaphy. The quality and durationof recovery were evaluated. HR dropped significantly from...