Moderately intense physical exercise alleviates electrocardiographic changes induced by cisplatin in rats.

1. INTRODUCTION AND OBJECTIVE: Cisplatin induces many collateral effects such as gastrointestinal disorders, nephrotoxicity, and dysautonomia. Recently our group showed that cisplatin treatment induces gastric emptying delay and that physical exercise and treatment with pyridostigmine prevent this change. In the current study, we investigated the role of moderate exercise on cardiac activity and autonomic balance in rats treated with cisplatin. 2. METHODS: Male Wistar rats were divided into Saline, Cisplatin, Exercise, and Exercise+Cisplatin groups. Cardiac and autonomic disorders were induced by (Cisplatin-3mg/kg, i.p once a week/per 5 weeks). Exercise consists of swimming (1 hour per day/5x day per week/per 5 weeks without overload). Forty-eight hours after the last session of the training or treatment, we assessed the cardiac activity and HRV via electrocardiogram analysis in DII derivation. 3. RESULTS: Cisplatin increase (p<0.05) R-R´ interval and decrease (p<0.05) heart rate vs. saline. Exercise+Cisplatin prevented (p<0.05) changes in R-R´ interval. Exercise per se induced bradycardia vs. saline group. We observed an increase in LF (nu) and a decrease in HF (nu) in the cisplatin group vs. saline. These changes were not significant. Moreover, cisplatin treatment increased (P<0.05) QT, QTc, and JT intervals compared with the saline group. In the Exercise+Cisplatin groups these increases were prevented significantly (p<0.05). 4. CONCLUSION: In the current study, chronic use of cisplatin induced electrocardiographic changes without altering autonomic balance. Moderate physical exercise prevented this phenomenon indicating that exercise can be beneficial in patients in chemotherapy.

Moderate exercise increases gastric accommodation in healthymen and women

Physical exercise can bring benefits to the cardiovascular and gastrointestinal tract. However, little is known about the adequate exercise intensity and how exercise responses are affects by sexual differences. AIMS: To evaluate the effect of an acute treadmill exercise session at ~ 75% of HRmáx on hemodynamic parameters and the gastric compliance of men and women. METHODS: The study included 22 men and women aged 18 to 29 years, physically active. The exercise consisted of a treadmill session at 75% of HRmáx. We monitored blood pressure (BP) and heart rate (HR). During the drink test, volunteers were asked to ingest 15mL of chocolate in 1min intervals, marking their satiety on a graphical scale combining verbal descriptors. RESULTS: There was a significant increase of hemodynamic parameters for both sexes after the exercise session (p <0.05). Exercise was also able to increase total ingested volume, time of ingestion and calories ingested (p < 0.05). Concerning the drink test, no influence of the exercise session on satiety scores was observed in the groups studied (p > 0.05). CONCLUSIONS: Acute moderate exercise promoted significant increase in hemodynamic parameters and gastric compliance in subjects of both sexes. However, there was no effect on the satiety scores and the volume ingested at each score

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Efeito da prática de capoeira sobre os parâmetros cardiovasculares / Effect of capoeira on cardiovascular parameters

Fundamentos: è extremamente importante avaliar os ajustes cardiovasculares promovidos pelos esportes de lutas, tendo em vista a inexistência de dados concisos na literatura. Objetivo: Avaliar e comparar os ajustes cardiovasculares e antropométricos de capoeiristas com indivíduos sedentários. Métodos: Foram avaliados o índice de massa corporéa (IMC) e a composição corporal além da pressão arterial (PA), frequência cardíaca (FC) e duplo-produto (DP) assim como o volume de oxigênio máximo (VO2máx) nos períodos de repouso e no 1°, 5° e 10° minutos em indivíduos capoeiristas e sedentários. Resultados: Houve aumento (p<0,05) no IMC no grupo dos capoeiristas. A FC no 1° munito foi maior (p<0,05) que a de repouso em ambos os grupos. No 1° minuto ambos os grupos apresentaram valores aumentados (p>0,05) de pressão arterial sistólica (PAS), pressão arterial média (PAM) e DP comparados ao repouso. Observaram-se valores maiores (p<0,05) de VO2máx nos capoeiristas. Conclusão: Os dados sugerem que a capoeira além de alterar o estado nutricional, promove ajustes cardiovasculares, melhorando a aptidão cardiopulmonar.