1.
RSC Adv
; 8(43): 24654-24659, 2018 Jul 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35557855
RESUMO
A facile and highly efficient method for the bromomethylation of thiols, using paraformaldehyde and HBr/AcOH, has been developed, which advantageously minimizes the generation of highly toxic byproducts. The preparation of 22 structurally diverse α-bromomethyl sulfides illustrates the chemo-tolerant applicability while bromo-lithium exchange and functionalization sequences, free radical reductions, and additions of the title compounds demonstrate their synthetic utility.