Advances in porphyrins and chlorins associated with polysaccharides and polysaccharides-based materials for biomedical and pharmaceutical applications.

Over the last decade, the convergence of advanced materials and innovative applications has fostered notable scientific progress within the biomedical and pharmaceutical fields. Porphyrins and their derivatives, distinguished by an extended conjugated π-electron system, have a relevant role in propelling these advancements, especially in drug delivery systems, photodynamic therapy, wound healing, and (bio)sensing. However, despite their promise, the practical clinical application of these macrocycles is hindered by their inherent challenges of low solubility and instability under physiological conditions. To address this limitation, researchers have exploited the synergistic association of porphyrins and chlorins with polysaccharides by engineering conjugated systems and composite/hybrid materials. This review compiles the principal advances in this growing research field, elucidating fundamental principles and critically examining the applications of such materials within biomedical and pharmaceutical contexts. Additionally, the review addresses the eventual challenges and outlines future perspectives for this poignant research field. It is expected that this review will serve as a comprehensive guide for students and researchers dedicated to exploring state-of-the-art materials for contemporary medicine and pharmaceutical applications.

Use of the CuFe2O4/biochar composite to remove methylene blue, methyl orange and tartrazine dyes from wastewater using photo-Fenton process.

In this study, CuFe2O4 ferrite was supported on biochar produced from malt biomass residues as a photocatalyst for degradation of methylene blue (MB), methyl orange (MO), and tartrazine (TZ) dyes. XRD, FT-IR, and FE-SEM were used to characterize the crystallinity and morphology of the samples. The characterization showed that the ferrite was uniformly supported on the surface of the biochar, confirming the formation of the composite. Degradation tests showed that CuFe2O4 degraded approximately 50, 47, and 62% of MB, MO, and TZ dyes, respectively, after 60 min of reaction. On the other hand, the CuFe2O4/biochar composite showed a significant increase in dye degradation, ~ 100%, for all three dyes. This increase in degradation efficiency may be due to less agglomeration of supported particles and due to decreased recombination of electron/hole pairs. Thus, results showed that the photocatalyst composite produced in this study is an effective alternative for removing dyes from wastewater.

Degradation of ramipril by residues from the brewing industry: A new carbon-based photocatalyst compound.

This study is a pioneer in the use of hydrochar as a support for photocatalytic oxide and its application and evaluation as a catalyst in degradation reactions of ramipril. Novel composites were easily prepared by the support TiO2 or ZnO nanoparticles on the malt bagasse hydrochar. The preparation of the hydrochar requires low synthesis temperature (250 °C), generating the energy savings of the process. The production of the new composites was well supported by different analytical techniques XRD, FTIR, SSA, SEM, EDS, and reflectance diffuse. The effect of different proportions of TiO2 or ZnO on the composites was investigated on the degradation efficiency of the pharmaceutical ramipril, without pH adjustment. Composites with a 5:1 hydrochar/TiO2 or ZnO ratio (MH5T and MH5Z, respectively) showed degradations of 72 and 98% of ramipril at 120 min. This remarkable performance may be associated with the decrease in band gap energy and the electron-hole recombination rate. In addition, the composites were more efficient than metal oxides pristine, and this may be related to the fact that hydrochar have a high concentration of phenolic, hydroxyl, and carboxylic functional groups on their surface. Radical identification tests indicated that h+, O2•-, and •OH were the reactive species involved in the degradation. The proposed mechanism was studied via LC-MS/MS indicated that the ramipril molecule degrades into low m/z intermediates in the first 60 min of reaction using the MH5Z.

Toxicity of acrylamide after degradation by conjugated (UV/H2O2) photolysis in microalgae.

Acrylamide (AA) is routinely used in laboratories and industries, and its disposal is always a problem; consequently, offering an alternative for their treatment contributes to conducting research in a responsible way. Therefore, in this work, acrylamide solutions were degraded by ultraviolet radiation and hydrogen peroxide (H2O2), and their toxicity was evaluated using a Desmodesmus quadricauda microalgae growth assay. The AA solutions were exposed to different dosages of H2O2 and different exposure times to UV radiation. The degradation was evaluated by liquid chromatography, which allowed the identification of the acrylamide peak and subsequent by-product peaks. A 100% degradation of the 1.5 mg L-1 AA solution with UV/H2O2 (0.034 g L-1) was achieved in just 10 min. The by-products formed did not inhibit the growth of D. quadricauda microalgae. The number of D. quadricauda individuals that grew in acrylamide solutions exposed to 20 and 30 min of UV radiation, with 0.034 g L-1 of H2O2, was very similar to the number of individuals that grew in the control solution. Thus, the treatment proposed in this work using H2O2 combined with ultraviolet radiation degraded acrylamide into by-products with reduced toxicity.

Relationship of the physicochemical properties of novel ZnO/biochar composites to their efficiencies in the degradation of sulfamethoxazole and methyl orange.

Three different composites were produced, based on zinc oxide and biochar (ZnO/biochar), varying the type of biomass (Salvinia molesta: SM; exhausted husk of black wattle: EH; and sugarcane bagasse: SB), with pyrolysis under mild conditions at 350 and 450 °C. Evaluation was made of the capacities of the composites for photocatalytic degradation of sulfamethoxazole antibiotic (SMX) and methyl orange dye (MO). The properties of the prepared composites were influenced by the biomass source, with larger crystallite size (SB), lower band gap energy (SM), higher specific surface area (SB), and larger pore size (SM) resulting in higher photocatalytic efficiency. Good degradation results were obtained using these innovative photocatalysts prepared at low temperatures, when compared to ZnO/biochar materials reported in previous studies. The best degradation capacities were obtained for the composites produced at 450 °C from SB and SM, with 99.3 and 97% degradation of SMX after 45 min, and 90.8 and 88.3% degradation of MO after 120 min, respectively.