Assuntos
Anormalidades da Pele/patologia , Doenças da Medula Espinal/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Anormalidades da Pele/complicações , Medula Espinal/diagnóstico por imagem , Medula Espinal/patologia , Doenças da Medula Espinal/complicações , Doenças da Medula Espinal/diagnóstico por imagemRESUMO
Cutaneous pseudolymphoma is an uncommon, benign lymphoproliferative disorder of the skin. Although this condition is most commonly idiopathic, its occurrence has been associated with cosmetic tattoos. We report a unique case of cutaneous pseudolymphoma that occured after accidental, traumatic inoculation of a red pigment in a healthy 33-year-old woman.
Assuntos
Corantes/efeitos adversos , Pseudolinfoma/diagnóstico , Dermatopatias/diagnóstico , Adulto , Betametasona/análogos & derivados , Betametasona/uso terapêutico , Biópsia , Feminino , Testa/patologia , Humanos , Lacerações , Transtornos Linfoproliferativos/diagnóstico , Transtornos Linfoproliferativos/etiologia , Pseudolinfoma/induzido quimicamente , Pele/patologia , Dermatopatias/induzido quimicamente , Triancinolona Acetonida/uso terapêuticoRESUMO
When two or more cutaneous tumours coexist in a single lesion, it is known as a cutaneous collision or contiguous tumour. Various combinations of collisions have been described. Collision tumours often have misleading clinical and histological presentations, and can be a diagnostic challenge. Chondroid syringomas are mixed cutaneous tumours of dual origin, and like collision tumours, are often confused with the more commonly seen cutaneous lesions. As chondroid syringomas are rare, their involvement in collision tumours is an even more peculiar occurrence. We report an unusual case of a cutaneous collision tumour on the nose involving an intradermal naevus and chondroid syringoma. To the best of our knowledge, this is the first time such a combination is reported.
Assuntos
Carcinoma Basocelular/diagnóstico , Ceratose Seborreica/patologia , Neoplasias Primárias Múltiplas/patologia , Nevo Pigmentado/patologia , Neoplasias Nasais/diagnóstico , Neoplasias Cutâneas/patologia , Idoso , Diagnóstico Diferencial , Feminino , HumanosRESUMO
There have been fewer than 60 cases of malignant teratocarcinosarcoma (TCS) described in the literature, usually arising in the nose and paranasal sinuses. The authors report on a patient who presented with neurological symptoms caused by a frontal lobe TCS, and in whom widespread spinal tumor dissemination developed. In rare cases, TCSs can occur with a predominantly cranial and neurological presentation and spread to the spinal canal.
Assuntos
Neoplasias Encefálicas/patologia , Sarcoma/patologia , Neoplasias da Coluna Vertebral/patologia , Teratocarcinoma/patologia , Adulto , Neoplasias Encefálicas/diagnóstico por imagem , Evolução Fatal , Humanos , Vértebras Lombares , Imageamento por Ressonância Magnética , Masculino , Tomografia por Emissão de Pósitrons , Sarcoma/diagnóstico por imagem , Teratocarcinoma/diagnóstico por imagemAssuntos
Povo Asiático , Fármacos Dermatológicos/efeitos adversos , Hidroquinonas/efeitos adversos , Ocronose/induzido quimicamente , Transtornos da Pigmentação/induzido quimicamente , Administração Cutânea , Feminino , Humanos , Melanose/tratamento farmacológico , Pessoa de Meia-Idade , Ocronose/etnologia , Ocronose/patologia , Transtornos da Pigmentação/etnologia , Transtornos da Pigmentação/patologia , Pele/patologiaRESUMO
The pathogenesis of inoculation cutaneous tuberculosis requires a break in the skin, through minor abrasions or injury, allowing the entry of tubercle bacilli. We report a 33-year-old man who presented with erythematous papules over a tattoo on the right upper arm, 1 month after undergoing a tattoo procedure. Histology and cultures revealed infection with Mycobacterium tuberculosis. He was started on a 9-month course of antituberculous medication and 3 months after initiation of the drugs all the papules had subsided. He has since completed the course of therapy and there has been no recurrence 1 year after treatment was started.
Assuntos
Tatuagem/efeitos adversos , Tuberculose Cutânea/diagnóstico , Adulto , Diagnóstico Diferencial , Humanos , Masculino , Tuberculose Cutânea/etiologia , Tuberculose Cutânea/patologiaRESUMO
Follicular mycosis fungoides (MF) is an uncommon histological variant of MF characterized by infiltrates of atypical lymphocytes around and within the epithelium of the hair follicles (folliculotropism). Here we report a patient with rapidly progressive follicular MF on the face, associated with concurrent typical MF lesions elsewhere. The histology was unusual, as apart from dense lymphoid infiltrates showing folliculotropism and epidermotropism, there was a prominent B-cell component with germinal centres, leading to an initial diagnosis of cutaneous B-cell lymphoma. The final diagnosis of follicular MF was established on demonstration of clonal T-cell receptor gene arrangements and lack of clonality for heavy chain gene rearrangements. This case illustrates a variant of MF that has a more rapid progression than the otherwise indolent course of classical MF over many years, and the diagnostic pitfalls, whereby the histology can mimic a B-cell proliferative disorder.
Assuntos
Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Linfócitos B , Diagnóstico Diferencial , Progressão da Doença , Face/patologia , Rearranjo Gênico do Linfócito T , Folículo Piloso/patologia , Humanos , Transtornos Linfoproliferativos , Masculino , Pessoa de Meia-Idade , Micose Fungoide/diagnóstico , Dermatopatias , Neoplasias Cutâneas/diagnósticoRESUMO
BACKGROUND: Only a minority of those infected with Helicobacter pylori will develop gastric cancer. Stratification of H. pylori strains based on carcinogenic potential will provide a basis for selective surveillance and eradication therapy. We studied the anti-H. pylori antibody profile in Asian patients with gastric adenocarcinoma to identify any H. pylori antigen that may be associated with an increased or decreased risk of gastric carcinoma. PATIENTS AND METHODS: A case-control study comparing the seroprevalence of antibodies with various H. pylori antigens in Singaporeans with gastric adenocarcinoma and the normal Singaporean population was carried out using both conventional immunoglobulin (Ig) G enzyme-linked immunosorbent assay (ELISA) and Western blot immunoassay. RESULTS: The seroprevalence among 44 gastric adenocarcinoma cases (70.5% males, mean age 66.7 +/- 13.5 years) and 261 controls (49.8% males, mean age 61.5 +/- 4.1 years) was 90.9% vs. 50.2% by IgG ELISA. In the H. pylori-positive male population, those suffering from gastric adenocarcinoma had significantly lower seroreactivity to the 35-kDa antigen compared with asymptomatic controls (p =.0198, OR = 3.79, 95% CI 1.24-11.61). Seropositivity to the 19.5 kDa antigen was also found to be associated with the presence of gastric adenocarcinoma in Singaporean males (p =.022, OR = 4.17, 95% CI 1.22-14.28). A 'high-risk' phenotype consisting of absence of a band at 35-kDa in combination with the presence of a band at 19.5-kDa was significantly associated with the presence of gastric adenocarcinoma (p =.002, OR = 3.7, 95% CI 1.6-8.6). CONCLUSIONS: Stratification of H. pylori strains based on their potential for carcinogenesis, such as those strains that are seropositive for the 19.5 kDa antigen and seronegative for the 35-kDa antigen, may provide a basis for selective eradication of H. pylori infection and future vaccine development.
Assuntos
Adenocarcinoma/microbiologia , Anticorpos Antibacterianos/sangue , Antígenos de Bactérias/imunologia , Helicobacter pylori/imunologia , Neoplasias Gástricas/microbiologia , Adenocarcinoma/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Western Blotting , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Feminino , Infecções por Helicobacter/imunologia , Infecções por Helicobacter/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Estudos Soroepidemiológicos , Singapura/epidemiologia , Neoplasias Gástricas/imunologiaRESUMO
Originally described in the pleura, solitary fibrous tumour (SFT) is now reported in a variety of extrapleural sites. However, description of SFT in the deep soft tissue of the neck is very rare. In this report, we document the neoplasm, deep to the right platsyma muscle but superficial to the deep fascia just above the clavicle, in an otherwise well 50-year-old Chinese man. Histological examination of the excised specimen disclosed spindle-shaped cells disposed in short fascicles as well as randomly in association with areas of varying cellularity, keloidal hyalinisation of the stroma and haemangiopericytoma-like vessels. The tumour cells were CD34-, bcl-2- and CD99-positive. Since histological features may not accurately predict the biological behaviour of this tumour, careful long-term follow-up is advocated.