[Health demands in adolescence. The results of 2 epidemiological studies in the Padua area in 1990-1992]. / Domanda di salute in adolescenza. Risultati di 2 indagini epidemiologiche nel padovano negli anni 1990-1992.

UNLABELLED: In order to make a detailed analysis of the specific requirements of adolescent health in this country, local health unit n. 19 in Padua performed an epidemiological survey with the collaboration of 15 general physicians who were asked to record all ambulatory visits by 13-24 year olds on a special form. The survey, which lasted two years, revealed that of a total of 4748 records, 2112 (44.48%) were male and 2636 (55.51%) were female. The age at which the greatest number of visits was recorded was 18. The majority of adolescents attended alone (68.48%) and this pattern tended to increase with age. The frequency of annual attendance was 86.64%. In order of frequency, diagnoses included: requests for certificates and prescriptions (21.76%); respiratory disease and influenza (21.61%); obstetric and gynecological problems (8.61% of the total and 15.52% of female attendance) which together with auxoendocrinological problems amounted to a frequency of 10.55%; psychological problems (6.53%); dermatological diseases (6.324%); problems involving the osteomuscular structure, problem of the digestive tract (4.93%); nervous disorders and diseases of the sense organs (4.87%); medication and requests for information (3.60%); nephro-uro-andrological problems (3.26%). IN CONCLUSION: the high rate of attendance at medical clinics does not show that adolescents are an often ill population but that the doctor has been selected as the prime interlocutor for all health-related problems. It should also be pointed out that the majority of problems tend to be reported as somatic, whereas only a minimum part (6.53%) are classified as psychological. This analysis confirms, however, that the health requirements presented as somatic often involve a psychological component.

Cisplatin plus vindesine versus cisplatin plus VP16 versus doxorubicin plus cytoxan in non-small-cell carcinoma of the lung. A randomized study.

From March 1981 to January 1984, 116 patients with advanced non-small-cell carcinoma of the lung (NSCCL) were randomly assigned to 3 combinations as follows: CDDP + DVA, CDDP + VP16 and DXR + CTX. 94 patients were evaluable for response, 106 for toxicity and survival. Of 31 patients, 15 (48%; 3 CRs and 12 PRs) responded to CDDP + DVA; of 33 patients, 12 (36%, 2 CRs and 10 PRs) responded to CDDP + VP16; of 30 patients, 3 (10%) obtained a PR with DXR + CTX (CDDP + DVA vs DXR + CTX, P less than 0.005; CDDP + VP16 vs DXR + CTX, P less than 0.05; CDDP + DVA vs CDDP + VP16, P = NS). The median duration of response was 22 weeks in the CDDP-DVA group, 17 weeks in the CDDP-VP16 group, and 16 weeks in the DXR + CTX group. No significant difference in survival was observed among the 3 groups (median: 43, 47, 41 weeks, respectively). Hematologic and neurologic toxicities were significantly higher in the DVA-containing regimen. Despite the lack of improvement of overall survival with the CDDP-containing combinations over the DXR + CTX control group, the good response rate makes them suitable to be used in combined therapeutic strategies.