RESUMO
We carried out a randomized, double-blind, placebo-controlled trial of Nonathymulin (NT, synthetic serum thymic factor) in patients with evolutive multiple sclerosis (MS) and moderate disability. Forty matched patients were treated with subcutaneous NT or placebo for 6 months and followed for another 6 months. There was no significant difference in treatment and control groups in the Kurtzke. Disability scores, Ambulation Index and Functional Scale. No significant side effects were recorded. NT is not effective in treating evolutive and moderately disabled MS.
Assuntos
Esclerose Múltipla/tratamento farmacológico , Fator Tímico Circulante/uso terapêutico , Hormônios do Timo/uso terapêutico , Adulto , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fator Tímico Circulante/efeitos adversosRESUMO
The antiviral activity of a novel biological response modifier (murabutide MDP derivative) has been investigated in 3-week-old OF1 mice infected with influenza (A/Texas/1/77) virus. In each experimental and control group, 10 mice were infected intranasally with a viral dose producing 50% mortality in 5 days and received murabutide via the subcutaneous or intranasal route at various doses either in a simple or in daily repeated administration. All experiments were done in triplicate. Significant prophylactic or therapeutic effects were observed when murabutide was administered the same day as virus, 4 days or 2 days before virus, and 2 days later. These effects varied with the route of administration and the doses of the compound.
Assuntos
Acetilmuramil-Alanil-Isoglutamina/análogos & derivados , Infecções por Orthomyxoviridae/prevenção & controle , Acetilmuramil-Alanil-Isoglutamina/administração & dosagem , Acetilmuramil-Alanil-Isoglutamina/uso terapêutico , Administração Intranasal , Animais , Relação Dose-Resposta a Droga , Vírus da Influenza A Subtipo H3N2 , Vírus da Influenza A , Injeções Subcutâneas , CamundongosAssuntos
Rejeição de Enxerto/efeitos dos fármacos , Imunossupressores/farmacologia , Peptídeos Cíclicos/farmacologia , Transplante de Pele , Animais , Relação Dose-Resposta Imunológica , Feminino , Antígenos H-2/imunologia , Antígeno H-Y/imunologia , Ativação de Macrófagos/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos A , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBAAssuntos
Macrófagos/efeitos dos fármacos , Peptídeos Cíclicos/farmacologia , Animais , Antineoplásicos , Bactérias/efeitos dos fármacos , Quimiotaxia/efeitos dos fármacos , Glucosamina/metabolismo , Técnicas In Vitro , Camundongos , Parasitos/efeitos dos fármacos , Fagocitose/efeitos dos fármacos , Ratos , Ratos Endogâmicos F344 , Estimulação Química , Superóxidos/metabolismoAssuntos
Reação Enxerto-Hospedeiro/efeitos dos fármacos , Ativação Linfocitária/efeitos dos fármacos , Linfócitos/imunologia , Peptídeos Cíclicos/farmacologia , Animais , Teste de Cultura Mista de Linfócitos , Camundongos , Camundongos Endogâmicos C57BL/imunologia , Camundongos Endogâmicos CBA/imunologia , Baço/imunologiaRESUMO
The use of both SEM and TEM techniques in studying the alterations of the columnar ciliated epithelium of the whole respiratory tract of ferrets enables the authors to find a significant discrepancy between tracheal and nasal mucosa destructions. This discrepancy is not a function of the anatomical location of virus instillation. Theoretical and pratical meanings are discussed.