RESUMO
Plasma gastrin and somatostatin concentrations were measured by radioimmunoassay in exclusively formula-fed infants and in breast-fed infants receiving supplementary formula during the first five postnatal days. Infants exclusively formula fed had a progressive increase in mean plasma gastrin concentration from 109 +/- 42 pmol/l (mean +/- SD) on the first day to 236 +/- 103 pmol/l on the fifth day after birth (p = 0.0001). Breast-fed infants receiving supplementary formula had similar hormone concentrations as formula-fed infants of corresponding postnatal age and they also had a significant increase in hormone levels from the first to the fifth day (p = 0.0001). A positive relationship was found between gastrin concentration and ingested milk volume: Rs = 0.51, n = 105, p = 0.0001. The high gastrin concentrations most probably reflect enhanced hormonal release from the gastrin-producing cells in response to increasing volumes of milk ingested by the infant. The mean plasma somatostatin concentration on the first day after birth was 18 +/- 6 pmol/l. No significant change occurred during the first five postnatal days, independent of feeding type.
Assuntos
Alimentos Fortificados , Gastrinas/sangue , Alimentos Infantis , Recém-Nascido/fisiologia , Somatostatina/sangue , Feminino , Humanos , Masculino , RadioimunoensaioRESUMO
Plasma cholecystokinin concentrations were measured with radioimmunoassay in breast fed infants in Sweden (n = 101) and formula fed infants in Italy (n = 119). Blood samples were collected from the infants during the first five postnatal days, just before feeding in a cross-sectional way. We found no significant difference in the hormone concentration in relation to age, in breast fed or in formula fed infants. Breast fed infants had significantly higher plasma hormone concentrations than formula fed infants during the postnatal period 0-5 days: 2.8 pmol/l (1-10 pmol/l), median (range) versus 2.2 pmol/l (1-25 pmol/l), (P < 0.02). It cannot be excluded that the results were influenced by the circumstances that the samples were collected from two separate populations. However, the higher hormone levels in breast fed infants may also be the expression of the fact that natural feeding per se promotes cholecystokinin secretion in newborn infants.
Assuntos
Aleitamento Materno , Colecistocinina/sangue , Alimentos Infantis , Recém-Nascido/sangue , Humanos , Redução de PesoRESUMO
The authors report the case of a seven year old girl originally diagnosed as a case of congenital ichthyosiform non-bullous erythroderma (Brocq). Further specific examination of the hair led to a final rare dual diagnosis of congenital ichthyosiform non-bullous erythroderma and Netherton's disease.
