RESUMO
We studied histophysiological changes in organs of the immune system, liver, and lungs of Wistar rats at delayed terms after ovariectomy. On day 52 after surgical castration leading to a decrease in estradiol, progesterone, and testosterone levels, activation of the immune system was revealed characterized by stage I accidental thymus involution, while pulp depletion in the spleen, and enhanced IL-2 and IFN-γ production. We also observed small-droplet degeneration of hepatocytes and reactive changes in the lungs manifested in increased number of neutrophils in the interalveolar septa.
Assuntos
Hepatócitos/imunologia , Fígado/imunologia , Pulmão/imunologia , Neutrófilos/imunologia , Baço/imunologia , Timo/imunologia , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Estradiol/sangue , Feminino , Hepatócitos/patologia , Interferon gama/sangue , Interleucina-2/sangue , Fígado/metabolismo , Fígado/patologia , Pulmão/metabolismo , Pulmão/patologia , Neutrófilos/patologia , Ovariectomia , Progesterona/sangue , Ratos , Ratos Wistar , Baço/metabolismo , Baço/patologia , Testosterona/sangue , Timo/metabolismo , Timo/patologia , Fatores de TempoRESUMO
Differences in the immune and inflammatory response were revealed in the lungs of male and female Wistar rats on day 1 after administration of LPS in a dose inducing the development of acute bacterial endotoxemia. Females showed more pronounced morphofunctional signs of immune system activation than males: this was characterized by more severe accidental involution of the thymus, devastation of the splenic white pulp, and enhanced production of IL-4, IL-12, and TNF-α by splenocytes. In males, production of the above cytokines decreased and inflammation in the lungs was more pronounced at these terms.
