RESUMO
Sepsis-induced acute kidney injury (SAKI) is a frequent complication of infant sepsis that approximately doubles the mortality rate. The poor prognosis of these patients is a result of care that is mainly supportive, nontargeted, and usually begun only after symptoms of the systemic inflammatory response syndrome are observed. Preclinical studies from relevant rodent models of SAKI suggest that mitochondria-targeted antioxidants may be a new mode of therapy that could promote recovery.
Assuntos
Injúria Renal Aguda/tratamento farmacológico , Antioxidantes/uso terapêutico , Mitocôndrias/efeitos dos fármacos , Compostos Organofosforados/uso terapêutico , Piperidinas/uso terapêutico , Sepse/complicações , Animais , Modelos Animais de Doenças , Humanos , Lactente , Camundongos , Mitocôndrias/metabolismo , RatosRESUMO
We present a case of serious treatment-refractory acyclovir- and foscarnet-resistant herpes simplex virus (HSV) type-1 orolingual infection that responded to oral cidofovir rinses after failure of acyclovir and foscarnet therapy. The use of 3% cidofovir in a saline rinse for refractory mucosal HSV infection appears promising but needs prospective evaluation.
Assuntos
Antivirais/administração & dosagem , Citosina/análogos & derivados , Herpesvirus Humano 1/isolamento & purificação , Organofosfonatos/administração & dosagem , Estomatite Herpética/tratamento farmacológico , Estomatite Herpética/imunologia , Administração Tópica , Antivirais/efeitos adversos , Cidofovir , Citosina/administração & dosagem , Citosina/efeitos adversos , Farmacorresistência Viral Múltipla , Feminino , Humanos , Hospedeiro Imunocomprometido , Pessoa de Meia-Idade , Antissépticos Bucais , Organofosfonatos/efeitos adversos , Transplante de Células-Tronco , Estomatite Herpética/virologiaRESUMO
The running behavior and biochemical markers of oxidative and glycolytic activities associated with voluntary running activity were studied in male Sprague-Dawley rats after 6 wk of training in exercise wheel cages. Twenty-four-hour recordings of running activity were used to quantify the number of individual running bouts, their duration and running speed, and the distance run per day. We then established three categories of voluntary running activity based on the mean distance run per day during the last 3 wk of training: low-activity runners averaged 2-5 km/day, medium runners 6-9 km/day, and high runners greater than 11 km/day. Each group demonstrated an intermittent, nocturnal running pattern, at relatively high intensities, with a similar mean running speed for all groups (avg approximately 45 m/min). Differences in total distance run per day were the result of variations in both the number and duration of individual running bouts. Specifically, high runners (n = 7) had 206 +/- 30 individual running bouts per 24 h, each lasting 87 +/- 7 s; medium runners (n = 7) 221 +/- 22 running bouts, lasting 47 +/- 5 s; and low runners (n = 7) 113 +/- 7 bouts, each lasting 40 +/- 7 s. Voluntary running depressed the rate of body weight gain compared with sedentary control rats, despite an increased food and water intake for all runners. Furthermore, drinking activity was temporally associated with running periods.(ABSTRACT TRUNCATED AT 250 WORDS)
