RESUMO
A membrane stabilizing effect of endobronchial laser therapy and antioxidative drugs piracetam and solcoseril was studied in 83 patients with chronic bronchitis. Malonic dialdehyde was measured to evaluate effects of this treatment on cellular and humoral immunity, blood coagulation and lipid peroxidation. It was found that the addition of membrane stabilizers to standard therapy of chronic bronchitis lowered malonic dialdehyde concentrations while the addition of the stabilizers and endobronchial laser therapy relieved clinical symptoms earlier, improved parameters of immunity, hemostasis and lipid peroxidation.
Assuntos
Actiemil/uso terapêutico , Bronquite/terapia , Piracetam/uso terapêutico , Adulto , Bronquite/complicações , Bronquite/imunologia , Doença Crônica , Terapia Combinada , Coagulação Intravascular Disseminada/etiologia , Coagulação Intravascular Disseminada/imunologia , Coagulação Intravascular Disseminada/terapia , Quimioterapia Combinada , Estudos de Avaliação como Assunto , Humanos , Terapia a Laser , Pessoa de Meia-Idade , Insuficiência Respiratória/etiologia , Insuficiência Respiratória/imunologia , Insuficiência Respiratória/terapiaRESUMO
An attempt of cryo-apheresis treatment of cortisol dependent bronchial asthma demonstrated high efficacy of this method: the majority of the patients could do without glucocorticoid maintenance, recovered working ability. Remission duration considerably increased.
Assuntos
Asma/terapia , Remoção de Componentes Sanguíneos , Glucocorticoides/uso terapêutico , Adulto , Asma/tratamento farmacológico , Temperatura Baixa , Estudos de Avaliação como Assunto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de TempoRESUMO
The results of clinico-immunologic studies of the efficacy of dioxidin in persons abusing alcohol have demonstrated that unlike antibiotics, dioxidin does not provoke any immunosuppressive disorders. It is recommended that dioxidin should be included into multimodality treatment of patients with acute lung abscesses, abusing alcohol.
Assuntos
Consumo de Bebidas Alcoólicas/fisiologia , Alcoolismo/imunologia , Anti-Infecciosos/uso terapêutico , Abscesso Pulmonar/imunologia , Quinoxalinas/uso terapêutico , Doença Aguda , Adulto , Idoso , Consumo de Bebidas Alcoólicas/efeitos dos fármacos , Alcoolismo/sangue , Alcoolismo/complicações , Antibacterianos/uso terapêutico , Terapia Combinada , Avaliação de Medicamentos , Feminino , Humanos , Imunidade/efeitos dos fármacos , Imunidade/imunologia , Peroxidação de Lipídeos/efeitos dos fármacos , Abscesso Pulmonar/sangue , Abscesso Pulmonar/tratamento farmacológico , Abscesso Pulmonar/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
An attempt has been made to replace antibiotics by chlorophyllypt (0.25 per cent solution in physiological sodium chloride solution administered by intravenous drip). The clinical, laboratory and X-ray parameters in 22 patients treated by this drug normalized in earlier terms than those in 19 patients who received the traditional antibiotic therapy. Chlorophyllypt was found to have the immunocorrective effect manifested by the normalization of the T-lymphocyte number and their theophylline-resistant subpopulation. No such an effect was achieved when broad-action antibiotics were used.
Assuntos
Clorofila/uso terapêutico , Extratos Vegetais/uso terapêutico , Pneumonia Pneumocócica/tratamento farmacológico , Pneumonia Estafilocócica/tratamento farmacológico , Doença Aguda , Adjuvantes Imunológicos/imunologia , Adulto , Idoso , Ensaios Clínicos como Assunto , Combinação de Medicamentos/uso terapêutico , Feminino , Humanos , Imunoglobulinas/análise , Contagem de Leucócitos/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Pneumonia Pneumocócica/imunologia , Pneumonia Estafilocócica/imunologia , Formação de Roseta , Linfócitos T/efeitos dos fármacos , Linfócitos T/imunologiaRESUMO
The complexity of the treatment of acute suppurative pulmonary diseases has been aggravated recently by the growth of microbial resistance to antibiotics and enhancement of the allergy incidence among the population. This circumstance restricts the use of antibiotic on a broad scale in clinical practice and makes the researchers go in studies of adequate substitutes. In the given case, use was made of chlorophyllipt. It was given to patients by intravenous drip in the form of a 0.25% solution based on saline twice a day. To increase local deposition of the administered antimicrobial drug in the affected area, interstitial electrophoresis was employed. In the patients' group on chlorophyllipt, the clinico-laboratory and x-ray parameters returned to normal earlier. Chlorophyllipt was noted to produce an immunocorrective action characterized by the normalization of the absolute count and percentage of E-RFC and theophylline-resistant-RFC. This action could not be observed in the patients' group receiving only antibiotics.