RESUMO
An elderly diabetic male with pneumonia presented with multiorgan failure. He developed hypoglycemic episodes with moxifloxacin that responded only to withdrawal of moxifloxacin.
Assuntos
Antibacterianos/efeitos adversos , Compostos Aza/efeitos adversos , Hipoglicemia/induzido quimicamente , Quinolinas/efeitos adversos , Idoso , Diabetes Mellitus Tipo 2/tratamento farmacológico , Infecções por Escherichia coli/tratamento farmacológico , Fluoroquinolonas , Humanos , Insulina/uso terapêutico , Masculino , Moxifloxacina , Pneumonia Bacteriana/tratamento farmacológicoRESUMO
Recurrence of amebic liver abscess is uncommon. We report a 62-year-old man presenting with amebic liver abscess thrice in last 5 years.
Assuntos
Entamoeba histolytica/isolamento & purificação , Abscesso Hepático Amebiano/diagnóstico por imagem , Abscesso Hepático Amebiano/terapia , Metronidazol/uso terapêutico , Antiprotozoários/uso terapêutico , Terapia Combinada , Drenagem/métodos , Esquema de Medicação , Entamoeba histolytica/efeitos dos fármacos , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Retratamento , Medição de Risco , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X , Ultrassonografia DopplerRESUMO
Chronic pancreatitis (CP) is characterized by progressive fibrosis, pain and/or loss of exocrine and endocrine functions. With the identification and characterization of pancreatic stellate cells (PSCs), the pathogenesis of CP and pancreatic fibrosis is now better understood. Molecular mediators shown to regulate the pathogenesis include transforming growth factor-beta, platelet-derived growth factor, and proinflammatory cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha. Besides these, the roles of cyclooxygenase (COX)-2 and apoptosis-related proteins have also been implicated in the pathogenesis. Furthermore, molecular pathways involving mitogen-activated protein kinases, phosphatidylinositol 3-kinase, Ras superfamily G proteins, serine threonine protein kinase Raf-1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) have been elucidated. Newer pathobiologic concepts concerning pain generation have also been put forward. Understanding the pathogenesis has led to the identification of novel molecular targets and the development of newer potential therapeutic agents. Those found to retard the progression of experimental CP and fibrosis in animal models include antioxidants, a Japanese herbal medicine called Saiko-keisi-to (TJ 10), the PPAR-gamma ligand troglitazone, the protease inhibitor Camostat mesilate, and Lovastatin.
Assuntos
Pancreatite Crônica/diagnóstico , Pancreatite Crônica/tratamento farmacológico , HumanosRESUMO
We report a 24-year-old woman and a 58-year-old man who developed short-segment esophageal strictures in the upper and mid esophagus two weeks after ingestion of aluminium phosphide tablets. They responded well to endoscopic dilatation.
