A piperazine- modified Schiff base sensor for highly selective detection of Zr (IV) ions: unveiling its antioxidant potential and regulatory effects on Zea mays growth.

Piperazine functionalized Schiff bases 4(a-c) were synthesized by a condensation reaction which were thoroughly characterized by using various spectroscopic techniques like 1H NMR, 13C NMR, IR and mass spectrometry. X-ray crystallography was used to analyse synthesized compound 4b. The sensing capability of 4b was investigated towards the tetravalent form of the zirconium ion among other metal ions. The limit of detection and the association constant, were calculated to be 56.4 × 10-8 M and 5.36 × 105 M-1 respectively. The inclusion of additional metal ions had no effect on the selectivity of sensor 4b. The binding mechanism was clarified using 1HNMR spectroscopy, which was further verified computationally, using DFT. Also, the seed germination experiments were performed and effect of compound 4b was analyzed on the seedlings of Zea Mays. An investigation into molecular docking study using (5HQX) protein revealed that it had inhibitory effects on cytokinin oxidase. The protein and ligand effectively associate, as indicated by the lower binding energy of -9.69 kcal/mol. Therefore, compound 4b can act as a good, powerful inhibitor against cytokinin oxidase.

Hybrid silica nanoparticles functionalized with pyrazolone-tethered organosilane: Synthesis and application for Sn (II) ion sensing in tap water.

Pyrazolone tethered triazole functionalized organosilane and their hybrid silica nanoparticles (HSNPs) have been synthesised for the selective detection of Sn(II) using spectrophotometric techniques. The prepared compounds are characterized by FT-IR, NMR (1H and 13C), XRD, mass spectrometry and FE-SEM spectral analyses. The synthesized hybrid silica nanoparticles gave improved detection limit of 4.3 × 10-8 M and stoichiometry of complex between analyte and probe was found to be 1:1. The association constant calculated for organosilane and their HSNPs came out to be 9.54 × 104 M-1 and 7.47 × 104 M-1 while the presence of other ions showed no interference in the sensing behaviour. The results of the use of this sensing system in tap water facilitate its applicability in real samples with the recovery % more than 98.

Detection of 2,4-dichlorophenoxyacetic acid in water sample by organosilane based silica nanocomposites.

The present study aims to produce nanocomposites of silica based organosilane as sensitive and selective fluorescent sensor for the recognition of 2,4 dichlorophenoxyacetic acid (2,4-D). Hydrazone tethered triazole functionalized organosilane has been synthesized by the condensation reaction of 4-hydroxybenzaldehyde and phenyl hydrazine followed by Cu(I) catalysed cycloaddition of azide with alkyne. The prepared compound has been further grafted over silica surface and the synthesized materials were characterized by FT-IR, NMR (1H and 13C), XRD, mass spectrometry and FE-SEM spectral analyses. The prepared organosilane and its HSNPs have been utilized as an effective emission probe for the selective detection of 2,4 D with good linear relationship in the range of 0-160 µM and 0-115 µM and LOD value of 46 nM and 13.5 nM respectively. In the presence of other active species, the sensor shows minimal interference while the comparison with the previously reported techniques suggests it to be more desirable for the sensitive and selective detection of 2,4 D. Further, the real sample application for detection of 2,4 D was analyzed in field water and the HSNPs based sensing system gave recovery percentage of above 98 %.

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review.

The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its 'quicker' methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.

Molecular keypad controlled circuit for Ce(iii) and NO3 - ions recognition by µw synthesized silicon-embedded organic luminescent sensor.

This report demonstrates the mimicking of an electronic circuit diagram towards Ce(iii) ion sensing response supported by molecular keypads. The probe naphthyl based triazole linked silatrane (NTS) was efficiently synthesized using a series of microwave mediated reactions. The luminescent sensor NTS was explored for the ion sensing response towards Ce(iii) ions using DMSO and DMSO : H2O 4 : 1 (v/v) as solvent media, respectively. The role of water in Ce(iii) ion sensing was detected as 'turn-off' response that contradicts the 'turn-on' with DMSO. Further, the sensing of NO3 - ions by NTS-Ce(iii) ensemble was associated with blue shift on absorption maxima. These mimicking response studies were sketched as circuit diagrams assisted by molecular keypad behaviour as IMPLICATION output logic gate.