A Study of Histological and Clinical Parameters and Their Correlation With Lymph Node Metastasis and Two-Year Survival in 50 Cases of Oral Squamous Cell Carcinoma.

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is one of the most prevalent malignant neoplasms in South Asia and a major public health problem in India. The purpose of the study was to identify correlations among various clinicopathological parameters of OSCC in a tertiary care center in the Eastern Uttar Pradesh population of North India. The study is imperative due to the scarcity of available data from this region. METHODOLOGY: A retrospective observational study was conducted on the cases received in the Department of Pathology over the period of January 2021 to December 2021. The study analyzed cases of OSCC, focusing on various factors such as age, gender, habits, tumor site, tumor size, differentiation, tumor-stroma ratio, tumor-infiltrating lymphocytes, tumor budding, worst pattern of invasion, depth of invasion, perineural invasion, lymphovascular invasion, underlying bone and overlying skin involvement, regional lymph node metastasis, and overall two-year survival. RESULTS: The mean age of the patients was 47.80 ± 12.48 years, and the male-to-female ratio was 15.6:1. Buccal mucosa was the most frequently affected site followed by the tongue. Fifty-six percent of cases reported with a history of tobacco abuse. Thirty-six percent of the patients had regional lymph node metastasis and exhibited a strong association with younger age, substance abuse, higher tumor size, tongue as a site, moderate-to-poor tumor differentiation, low tumor-infiltrating lymphocytes, and higher perineural and lymphovascular invasion. Moreover, at the end of the two-year survival analysis, 34% of patients succumbed to the disease. Overall survival was observed to be significantly better with <2 cm maximum tumor size, well-differentiated tumor morphology, higher tumor-infiltrating lymphocytes, and no nodal metastasis. CONCLUSIONS: The study highlights the intricate correlations of various histopathological factors in OSCC, shedding light on their potential implications for prognosis.

Pseudosarcomatous Fibromyxoid Tumor of the Prostate: A Rare Benign Lesion Mimicking Malignancy.

Psuedosarcomatous fibromyxoid tumor (PSFT) is an uncommon, non-malignant yet locally aggressive pseudotumor found in the genitourinary system. Despite being a benign spindle cell tumor without any documented cases of metastasis, its local aggressiveness can pose a life-threatening risk. The lack of specific clinical symptoms and the infiltrative characteristics of the lesion may lead to misdiagnosis as sarcomatoid carcinoma or sarcoma. Therefore, it is crucial to distinguish PSFT histologically and through immunohistochemistry from other spindle cell tumors to avoid unnecessary investigations and treatments. This case emphasizes the difficulties in diagnosing this uncommon benign tumor because of its infrequent occurrence, limited literature, vague symptoms, and similarities in imaging results with inflammatory or infectious conditions, as well as sarcomatous neoplasms. Precise diagnosis plays a vital role in preventing unnecessary or insufficient treatment.

Primary Mucoepidermoid Carcinoma of the Lung Coexisting With Pulmonary Tuberculosis: A Rare Case Report.

Mucoepidermoid carcinoma (MEC) is a well-established neoplasm of the salivary glands. However, the MEC of the lung is an exceedingly rare neoplasm that falls under the category of salivary gland-type tumors of the lung. Pulmonary MEC is recognized for its indolent progression. Pulmonary tuberculosis (TB) is a prevalent infectious disease in India and ranks among the leading causes of death from infectious diseases. Nevertheless, the co-occurrence of pulmonary MEC with pulmonary TB is a rare phenomenon that has not been documented in the literature. In this report, we describe a 54-year-old male patient who presented with symptoms of dysphagia, weight loss, and fever. Histopathological examination diagnosed him with pulmonary MEC, and concurrent cytology and Gene-Xpert tests confirmed tuberculosis. This case represents the first documented instance of this particular co-occurrence. It underscores the limitations of radiology in diagnosing such a rare neoplasm, especially when there is an absence of lung parenchyma infiltration and a mass lesion. Additionally, this case supports the possibility of an interdependent relationship between malignancies and tuberculosis.

Latent distant metastasis of renal cell carcinoma to skin: A case report.

Renal cell carcinoma (RCC) is known to recur decades after nephrectomy; however, isolated cutaneous metastasis is rare. Previous clinical history plays vital role. Newly occurring skin lesions in follow-through patients of RCC should be carefully evaluated, and possibility of its metastasis should be acknowledged. Disease-free survival postmetastasectomy is possible.