Active dynamics of charged macromolecules.

We study the role of active coupling on the transport properties of homogeneously charged macromolecules in an infinitely dilute solution. An enzyme becomes actively bound to a segment of the macromolecule, exerting an electrostatic force on it. Eventually, thermal fluctuations cause it to become unbound, introducing active coupling into the system. We study the mean-squared displacement (MSD) and find a new scaling regime compared to the thermal counterpart in the presence of hydrodynamic and segment-segment electrostatic interactions. Furthermore, the study of segment-segment equal-time correlation reveals the swelling of the macromolecule. Further, we derive the concentration equation of the macromolecule with active binding and study how the cooperative diffusivity of the macromolecules get modified by its environment, including the macromolecules itself. It turns out that these active fluctuations enhance the effective diffusivity of the macromolecules. The derived closed-form expression for diffusion constant is pertinent to the accurate interpretation of light scattering data in multi-component systems with binding-unbinding equilibria.

Clustering of lipids driven by integrin.

Integrin is an important transmembrane receptor protein which remodels the actin network and anchors the cell membrane towards the extracellular matrix via mechanochemical pathways. The clustering of specific lipids and lipid-anchored proteins, which is essential for a certain type of endocytosis process, is facilitated at integrin-mediated active regions. To study this, we propose a minimal exactly solvable model which includes the interplay of stochastic shuttling between integrin on and off states with the intrinsic dynamics of the membrane. We propose a two-step mechanism in which the integrin induces an aster-like arrangement in the actin network, followed by clustering of lipids in that region. We obtain an analytic expression for the deformation and local membrane velocity, and thereby the evolution of clustering mediated by a single integrin. The deformation evolves nonmonotonically and its dependence on the stochastic shuttling timescales and membrane properties is elucidated. Our estimates of the area of the deformed region and the number of lipids in it indicate strong clustering.

Mean first-passage time of an active fluctuating membrane with stochastic resetting.

We study the mean first-passage time of a one-dimensional active fluctuating membrane that is stochastically returned to the same flat initial condition at a finite rate. We start with a Fokker-Planck equation to describe the evolution of the membrane coupled with an Ornstein-Uhlenbeck type of active noise. Using the method of characteristics, we solve the equation and obtain the joint distribution of the membrane height and active noise. In order to obtain the mean first-passage time (MFPT), we further obtain a relation between the MFPT and a propagator that includes stochastic resetting. The derived relation is then used to calculate it analytically. Our studies show that the MFPT increases with a larger resetting rate and decreases with a smaller rate, i.e., there is an optimal resetting rate. We compare the results in terms of MFPT of the membrane with active and thermal noises for different membrane properties. The optimal resetting rate is much smaller with active noise compared to thermal. When the resetting rate is much lower than the optimal rate, we demonstrate how the MFPT scales with resetting rates, distance to the target, and the properties of the membranes.

Time evolution of intermittency in the passive slider problem.

How does a steady state with strong intermittency develop in time from an initial state which is statistically random? For passive sliders driven by various fluctuating surfaces, we show that the approach involves an indefinitely growing length scale which governs scaling properties. A simple model of sticky sliders suggests scaling forms for the time-dependent flatness and hyperflatness, both measures of intermittency and these are confirmed numerically for passive sliders driven by a Kardar-Parisi-Zhang surface. Aging properties are studied via a two-time flatness. We predict and verify numerically that the time-dependent flatness is, remarkably, a nonmonotonic function of time with different scaling forms at short and long times. The scaling description remains valid when clustering is more diffuse as for passive sliders evolving through Edwards-Wilkinson driving or under antiadvection, although exponents and scaling functions differ substantially.

Skewness in (1+1)-dimensional Kardar-Parisi-Zhang-type growth.

We use the (1+1)-dimensional Kardar-Parisi-Zhang equation driven by a Gaussian white noise and employ the dynamic renormalization-group of Yakhot and Orszag without rescaling [J. Sci. Comput. 1, 3 (1986)]. Hence we calculate the second- and third-order moments of height distribution using the diagrammatic method in the large-scale and long-time limits. The moments so calculated lead to the value S=0.3237 for the skewness. This value is comparable with numerical and experimental estimates.