[Migraine: dynamics of psychophysiologic pattern]. / Migren': dinamika psikhofiziologicheskogo patterna.

85 patients with migraine without aura and 20 healthy individuals were examined between the attacks, before the attack, during and after it (1-2 days). The examination included clinical-neurological analysis; psychological Spilberger's and Beck's tests, scale of alexithymia and complex algesic questionnaire; recording of the conditional negative wave; determination of nociceptive flexor reflex; recording of trigeminal evoked potentials; spectral analysis of the heart's rhythms; polysomnographic study. Psychophysiologic pattern characteristic for all the patients was established. Psychological and neurophysiological parameters changed synchronously in the periods before the attack, during and after it. Before the migraineous attack a specific pathologic integration increased and presented maximally (the activity of antinociceptive system weakens anxiety increased, tension of catecholaminergic systems grew, hyperactivity in trigeninal sphere elevated, tolerance to the pain decreased). A clear tendency to the reversibility of these changes was observed after an attack. A dynamics revealed in the psychophysiological pattern could serve as a predictor of a migraineous attack and open some perspectives for prophylaxis of the algesic attack.

[Changes in evoked slow cerebral potential (contingent-negative variation) in epilepsy]. / Izmeneniia vyzvannogo medlennogo potentsiala golovnogo mozga (kontingentno-negativnogo otkloneniia) pri epilepsii.

Contingent negative variation (CNV) was examined in 14 epileptic patients (5 with generalized and 9 with partial fits) both before and after 24 hours of sleep deprivation. Background CNV indices differed significantly by higher amplitudes of nearly all CNV components from the ones of healthy individuals. Amplitudes of postimperative negative waves (PINW) and general waves differed most of all. After sleep deprivation there was an PINW increase as well as the tendency to the late CNV component amplitude's increase. Elevation of CNV amplitudes after sleep deprivation was more pronounced in patients in which the deprivation provoked development of epileptic fits in comparison with patients which endured sleep deprivation rather favourably. The changes revealed in CNV components of the patients with epilepsy were considered in terms of disorders in regulatory mechanisms at the level of apical dendrites of cortical neurons' excitation.

[The adaptive capacities of patients with panic disorders (a psychophysiological study)]. / Adaptivnye sposobnosti bol'nykh panicheskimi rasstroistvami (psikhofiziologicheskoe issledovanie).

Contingent-negative deviation (CND) and orientational reaction (OR) were studied in 9 women suffering from typical (according to DSM-III-R) panic disorders (PD) and 12 healthy females. CND recording was made after giving neutral (70 dB, 1000 Hz) and stress (120 dB, 2000 Hz) pairs of sounds. Patients with PD were divided in two groups depending upon CND amplitudes. The first group (4 patients) was distinguished from healthy individuals by high CND amplitude (which significantly decreased after reaction on stress sound), by delay of extinction of cutaneogalvanic reaction (CGR) and by higher electromyogram amplitude. The second group (5 patients with more severe course of PD) was characterized by low amplitudes of CND and electromyogram, by absence of changes in CND after stress sound, by delay of extinction of CGR and nonspecific response. Above-mentioned data were evidence of psychophysiological heterogeneity of typical PD. The results were interpreted from a position of adaptive abilities of patients with PD, using ineffective and immature psychophysiological strategies of overcoming stress.

[Sulpiride in the prophylactic treatment of migraine]. / Sul'pirid v profilakticheskom lechenii migreni.

The aim of the work was investigation of both efficacy of sulpiride, atypical neuroleptic drug with pronounced antidepressive activity, and its influence on central nervous system. The study was performed in the course of prophylactic treatment of migraine using contingent negative variation (CNV) index. It is demonstrated that sulpiride is effective in prophylactic treatment of migraine complicated with psychologic disorders and autonomic dysfunctions. Such effect may be caused by the drug's influence on depression, anxiety, autonomic symptoms, tension-type headaches. This conclusion was confirmed by CNV data, change of which after sulpiride administration have indicated normalization of mental performance and increase of active adaptive abilities.

[A comparative psychophysiological analysis of anxiety disorders of a permanent and paroxysmal nature]. / Sravnitel'nyi psikhofiziologicheskii analiz trevozhnykh rasstroistv permanentnogo i paroksizmal'nogo kharaktera.

Observation of patients with panic disorders (PD) and generalized anxious disturbances (GAD) by means of contingent negative variation (CNV) revealed that they significantly differ from healthy individuals. Anxiety, depression and autonomic dysfunction were more pronounced in such patients. Both high amplitude of early CNV component and alteration of its habituation were quite typical for patients with PA in contrast to GAD patients and healthy individuals. There were no differences in CNV indices between the healthy group and the patients with GAD. PA patients differed from GAD ones by smaller manifestation of depression, shorter duration of the disease, shorter time of reaction. The data obtained have demonstrated qualitative psychophysiologic differences between PA and GAD groups of patients. They were mostly pronounced in both amplitude of early CNV and alteration of its habituation. PA patients were characterized by an increase of excitability in brain cortex and by surplus orientation activity. The authors suppose that specific CNV pattern reflects neurodynamics of "paroxysmal brain".