[Features of the effect of ukrinol on the phospholipid spectrum in white rat whole blood and erythrocyte membranes in a chronic experiment]. / Osobennosti deistviia ukrinola na spektr fosfolipidov tsel'noi krovi i membran éritrotsitov belykh krys v khronicheskom éksperimente.

Qualitative composition and quantitative changes of phospholipids of the whole blood and membranes of white rats erythrocytes have been studied as affected by ukrinol. Regularities in the change of phylogenetically stabilized phospholipid-phospholipid relations in the studied biological systems have been found under the long-term effect of ukrinol on the organism. The ways of normalizing of the disturbed phospholipid metabolism under ukrinol intoxication are discussed.

[The capillary system of the rat heart in occlusion of the coronary artery]. / Sistema kapilliarov serdtsa krys pri okkliuzii venechnoi arterii.

In 74 white rats by means of non-injection++ method morphofunctional state of the myocardial capillary bed has been studied in dynamics at occlusion of descending branch of the left coronary artery. During the first week after the operation blood supply of the areas, adjoining the necrosis, increases at the expense of dilatation and some increase in number of functioning capillaries, that results in enlargement of the exchanging surface and capacity of the capillary bed. Beginning from the 12th day, the value of all these parameters decreases, however, they do not reach their initial level. By the end of the experiment (45 days) the number of the functioning capillaries somewhat decreases, but the capillary diameters remain increased. By that time in the myocardial areas, adjoining the necrosis a parviansiform capillary network without a definite orientation, concerning muscle fibers, has been formed.

The effect of alpha-tocopherol and Intal on heart capillary bed and lipid peroxide oxidation in experimental necrosis of the rat myocardium.

The effect of Intal and alpha-tocopherol on the morphofunctional state of myocardial capillary bed and peroxide oxidation of lipids (POL) was studied in 160 albino rats with coronary artery occlusion. The vascular effect of Intal consisted in increasing the number of functioning capillaries and enlargement of their exchange surface. alpha-tocopherol proved to be less effective in this respect. The authors assume that besides its influence on myocardial microcirculation through POL reduction, Intal supports the increase in the number of functioning capillaries.

Combined action of indomethacin and adrenalin on morphofunctional heart indicators.

The influence of simultaneous administration of indomethacin and adrenalin on heart microcirculation, myocardial blood flow, peroxide lipid oxidation in the heart muscle homogenate and myocardial contractility was studied in male albino rats and in the myocardium of 6-7 days old chicken embryos. Intramuscular adrenalin administration in a dosis of 2 mg/kg led to a considerable reduction of the exchange surface of the capillaries and to a slow-down of blood flow in myocardial tissue, an increase in the lipid peroxide content in the heart muscle, and to an acceleration of the heart rate with the development of arrhythmia. Indomethacin abolished haemodynamic and metabolic myocardial disorders generated by toxic doses of adrenalin hydrochloride. It had also a cardiotonic and anti-arrhythmic effect: it abolished arrhythmia brought about by aconitine and adrenalin in the culture of the embryonal chicken myocardium explantate. These up to the present unknown cardiotonic, anti-arrhythmic and adrenoprotective properties of indomethacin can contribute to a substantial broadening of its therapeutical application.

Capillary system of rat myocardium in experimental hypertrophy and physical exercise.

The authors investigated in 90 albino rats, by means of a new non-injection method, the morpho-functional state of the capillary system in various parts of the myocardium in a normal state, in hypertrophy of varying degree and during physical exercise. It was found that the density, the surface are (CSA) and the capacity of the capillary bed of the right ventricle are larger than in the left ventricle. The increase in capillary blood supply in a hypertrophic myocardium occurs in parallel with the development of the hypertrophy and at rest fully corresponds to the increased myocardial mass. However, at maximal physical load the capillary segment of blood supply to the myocardium functions insufficiently, which is evidenced by a decrease in the working capacity of the experimental animals.

[State of the capillary network of rat myocardium in the presence of hypertrophy and physical loading]. / O sostoianii kapilliarnoi seti miokarda krys pri ego gipertrofii i pri fizicheskoi nagruzke.

Morphofunctional state of the capillary network in various myocardial parts was studied in white rats under normal conditions, myocardial hypertrophy of different degree and under physical loading. It was demonstrated that density, metabolic surface and capacity of the capillary bed is larger in the right ventricle than in the left one. The capillary blood supply in hypertrophied myocardium, increasing simultaneously with hypertrophy, at the state of rest corresponds to its increasing mass. On the contrary, under maximal physical loading functioning of the capillary part in the myocardium becomes unadequate that is evident from a decreasing activity of the test animals.