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1.
J Am Acad Dermatol ; 87(5): 1042-1048, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35690165

RESUMO

BACKGROUND: Fragrance is one of the common causes of immediate contact reaction. Knowing the prevalence of a reaction in a given population enables prioritization of allergy screening. OBJECTIVE: The purpose of this study was to determine the prevalence of an immediate patch test reaction to fragrance in patients with fragrance allergic contact dermatitis. METHODS: This prospective study enrolled 291 patients who were given standard patch tests for allergic contact dermatitis. Those with positive reactions were then asked to undergo additional patch tests to assess both immediate and delayed reactions to 28 different fragrance substances. RESULTS: Cinnamic aldehyde and cinnamic alcohol were the most frequently encountered substances in positive immediate reactions and standard (delayed) patch test reactions. Immediate patch reactions to benzyl alcohol, sorbic acid, and coumarin were more frequently observed than standard patch test reactions. LIMITATIONS: Because of the small sample size of patients who agreed to continue further patch testing evaluation, a statistical association between patient characteristics and fragrance-positive patch test reactions was difficult to establish. CONCLUSIONS: In this population, cinnamic aldehyde and cinnamic alcohol were the most common fragrance allergens causing both immediate and delayed reactions, whereas reactions to benzyl alcohol, sorbic acid, and coumarin were frequently observed in immediate patch tests.


Assuntos
Dermatite Alérgica de Contato , Perfumes , Acroleína/análogos & derivados , Alérgenos/efeitos adversos , Álcoois Benzílicos , Cumarínicos , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Humanos , Odorantes , Testes do Emplastro/efeitos adversos , Perfumes/efeitos adversos , Propanóis , Estudos Prospectivos , Ácido Sórbico
2.
Acta Derm Venereol ; 98(8): 742-747, 2018 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-29701234

RESUMO

Adult-onset immunodeficiency due to anti-interferon-γ autoantibody is an emerging acquired immunodeficiency with frequent skin manifestations. A retrospective chart review was conducted and identified 41 patients with the syndrome. Skin involvement was detected in 33 (80%) patients, 15 (45%) with infective skin diseases and 27 (82%) with reactive skin disorders. Reactive lesions were mostly neutrophilic dermatoses, e.g. Sweet syndrome. Of note, the presence of neutrophilic dermatoses was highly associated with infections of other sites. An adjusted odds ratio for the existence of infections in patients with neutrophilic dermatoses was 14.79 (95% CI: 5.13, 42.70; p < 0.001). Moreover, neutrophilic dermatoses were significantly correlated with opportunistic infections observed in those with defects in cell-mediated immunity including non-tuberculous mycobacterium and disseminated fungal infection. The odds ratio for opportunistic infections in the presence of neutrophilic dermatoses was 12.35 (95% CI: 5.00, 30.55; p <0.001). Thus, the presence of neutrophilic dermatoses in patients with the syndrome can signal opportunistic infections that warrant physician attention.


Assuntos
Autoanticorpos/imunologia , Autoimunidade , Hospedeiro Imunocomprometido , Síndromes de Imunodeficiência/imunologia , Interferon gama/imunologia , Infecções Oportunistas/imunologia , Pele/imunologia , Síndrome de Sweet/imunologia , Adulto , Idade de Início , Idoso , Autoanticorpos/sangue , Feminino , Humanos , Síndromes de Imunodeficiência/sangue , Síndromes de Imunodeficiência/diagnóstico , Síndromes de Imunodeficiência/epidemiologia , Masculino , Pessoa de Meia-Idade , Infecções Oportunistas/diagnóstico , Infecções Oportunistas/epidemiologia , Prevalência , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Pele/patologia , Síndrome de Sweet/sangue , Síndrome de Sweet/diagnóstico , Síndrome de Sweet/epidemiologia , Tailândia/epidemiologia
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