[The clinical efficacy of diltiazem and the means for enhancing it in treating patients with ischemic heart disease combined with chronic bronchitis]. / Klinicheskaia éffektivnost' diltiazema i puti ee povysheniia pri lechenii bol'nykh ishemicheskoi bolezn'iu serdtsa v sochetanii s khronicheskim bronkhitom.

The effect of diltiazem on hemodynamic and external respiration was studied in 93 patients with coronary heart disease concurrent with chronic bronchitis. During a course diltiazem therapy there were positive changes in central and regional pulmonary circulatory parameters, improved external respiration and higher tolerance exercise. The combined therapy with diltiazem and essentiale in patients with profound ventilation disorders resulted in more clinical benefits than diltiazem used alone in equivalent doses.

[The activity of lipid peroxidation and proteolysis in assessing the stability of the course and the prognosis of ischemic heart disease in patients with chronic bronchitis]. / AKtivnost' perekisnogo okisleniia lipidov i proteoliza v otsenke stabil'nosti techeniia i prognoza ishemicheskoi bolezni serdtsa u bol'nykh khronicheskim bronkhitom.

In combination of coronary heart disease with chronic obstructive bronchitis observed in 57 patients there appeared hyperactivity of lipid peroxidation and suppression of lipid antioxidant abilities. In aggravated chronic bronchitis, lipid peroxidation intensified still more, starting the chain of biochemical reactions which entailed further imbalance and inhibition of the antioxidant and proteolysis systems. This suggests the conclusion on the validity of introduction of antioxidants and proteolytic inhibitors into complex therapy of such patients.

[Lipid peroxidation and change in the lipid fraction of plasma in patients with hypertonic disease]. / Perekisnoe okislenie lipidov i izmenenie lipidnykh fraktsii plazmi krovi u bol'nykh gipertonicheskoi bolezn'iu.

Effect of lipid peroxidation on content and composition of blood plasma lipids was studied in 20 patients with hypertension within various periods after hypertonic crisis. Alterations in blood plasma lipid spectrum were shown to be related to initiation of lipid peroxidation in cell membranes. Dynamics of lipid peroxidation in individual blood plasma lipid fractions appears to reflect the adaptation under conditions of the pathological state of the organism.

[Lipid peroxidation in patients with hypertension and chronic pyelonephritis with arterial hypertension]. / Perekisnoe okislenie lipidov u bol'nykh gipertonicheskoi bolezn'iu i khronicheskim pielonefritom s arterial'noi gipertenziei.

++Non-ezymatic lipid peroxidation (LP) and total lipids (TL) in serum and erythrocytic membranes were studied in 42 hypertensive subjects and 35 chronic sufferers with pyelonephritis accompanied by arterial hypertension. The measurements performed at different phases of the clinical course provided evidence in favour of possible application of LP and TL tests in differentiating essential hypertension from chronic pyelonephritis with arterial hypertension.

[The function of membrane Ca-ATPases and nonenzymatic peroxidation of membrane lipids in patients with hypertension]. / Funktsiia membrannykh Ca-ATFaz i nefermentativnoe perekisnoe okislenie lipidov kletochnykh membran u bol'nykh gipertonicheskoi bolezn'iu.

Alterations in activity of membrane-bound Ca2(+)-ATPases were shown to depend on the rate of lipid peroxidation in cell membranes of patients with hypertension during the period of crisis. On the basis from these results antioxidants and Ca2(+)-antagonistic drugs could be used for treatment of hypertensive crisis. Monitoring of the disease is possible by means of estimation of the membrane-bound Ca2(+)-ATPases activity.

[Characteristics of the antioxidant activity of the blood plasma in patients with hypertension]. / Osobennosti antioksidantnoi aktivnosti plazmy krovi u bol'nykh gipertonicheskoi bolezn'iu.

A study of the peroxidation of lipids of erythrocytic membranes and blood plasma, antioxidant activity of the blood plasma in 59 patients with hypertensive disease revealed that the initial stages of the disease exacerbation increase of the antioxidant activity is caused by an intensification of peroxidation of cell membrane lipids. A less distinct increase of the antioxidant activity during remission may be due to changes of the blood plasma lipid composition.