[The level of malone dialdehyde in blood plasma as a manifestation of hepatic function in pilots of various professional categories]. / Uroven' malonovogo dial'degida plazmy krovi kak pokazatel' funktsional'nogo sostoianiia pecheni u letchikov razlichnykh professional'nykh kategorii]

Plasma levels of malone dialdehyde (MDA) were measured in flyers of various professional categories and persons who had no flight experience in normal conditions and shortly after a hypobaric hypoxia trial (30 min., P = 405 mm Hg, ascent and descent at 15-20 m/s), and after 24 hours of reoxygenation. In essentially healthy and highly adapted to periodic hypoxia flyers of the military transport aviation MDA remained within the normal range whereas in some subjects without flight experience displayed a significant increase in MDA levels during hypoxia and/or reoxygenation. Elevated baseline values and a material rise in MDA were also found in flyers whose blood bilirubin was above 20 mumol/L. The detoxicating function of the liver was disturbed in this category. A similar instability of the blood MDA is characteristic of subjects with hypertension, cranial traumata and obesity.