RESUMO
The intracameral injection of New Zealand white male rabbits with type 1 herpes simplex virus produced acute anterior uveitis with biphasic elevation of the intraocular pressure (IOP). The first IOP increase occurred on day 1 and 2 and the second increase on day 8. There was no significant correlation between the IOP changes and multiplication of herpes simplex virus in the uvea and cornea, nor between the IOP changes and histopathologic alteration of the tissue. Aspirin suppressed significantly the first as well as the second IOP elevation, whereas dexamethasone suppressed significantly only the second elevation.
Assuntos
Aspirina/farmacologia , Dexametasona/farmacologia , Pressão Intraocular/efeitos dos fármacos , Ceratite Dendrítica/tratamento farmacológico , Uveíte/tratamento farmacológico , Animais , Olho/patologia , Ceratite Dendrítica/microbiologia , Ceratite Dendrítica/patologia , Masculino , Oftalmoscopia , Coelhos , Simplexvirus/efeitos dos fármacos , Simplexvirus/crescimento & desenvolvimento , Uveíte/microbiologia , Uveíte/patologiaRESUMO
Of 34 species of Proteus isolated from human eyes, 29 (85%) were P. mirabilis and five (15%) were P. morganii. In vitro antibiotic sensitivity studies showed that gentamicin best controlled both P. mirabilis and P. morganii of all the antibiotics tested. In vivo tests on experimental Proteus infections of rabbit coreas, treated with gentamicin and tobramycin, yielded comparable clinical results, but gentamicin was more effective in eliminating the organism from the experimental lesions.
