[Role of lipases in human metabolism]. / Rola lipaz w metabolizmie czlowieka.

Lipases play a crucial role in the metabolism of lipids in humans. These enzymes can be classified according to the location: located in the digestive juices (lingual lipase, gastric lipase and pancreatic lipase), located intracellularly (hormone-sensitive lipase and lysosomal acid lipase) and in the endothelial cells (lipoprotein lipase and hepatic lipase). In this review, we discuss the interrelationships of lipases, their structure in humans, how they are affected by hormones and the clinical aspects of their deficiency.

Urine mutagenicity of petroleum plant workers.

The mutagenicity of urinary extracts from workers employed in a petroleum plant was analyzed by means of the plate test using S. typhimurium strains TA98 and TA100. Mean urinary mutagenic activities in TA98 were 2-14 times higher in the petroleum plant workers than in the control group. In TA100 these differences were even bigger, the mutagenicity in petroleum plant workers' urine being 3-42 times higher than in the control group. These results suggest that the environmental exposure of people to mutagenic substances is markedly increased in a petrochemical plant.

Effect of two-week ethanol administration on lipoprotein lipase activity and blood serum lipids in the rat.

Influence of ethanol administration on adipose tissue lipoprotein lipase activity, serum lipids in the rat. Intoxication caused a decrease of lipoprotein lipase activity. In some animals a rise of serum high density lipoprotein cholesterol was observed which correlated positively with the content of cytochrome P-450 in the liver.