Childhood asthma treatment based on indirect hyperresponsiveness test: Randomized controlled trial.

PURPOSE: The purpose of this study was to assess the usefulness of indirect airway hyperresponsiveness (AHR) test using hypertonic saline in determining the dose of inhaled corticosteroids (ICS) to maintain asthma control in children. METHODS: A group of 104 patients (7-15 years) with mild-moderate atopic asthma were monitored for their asthma control and treatment for 1 year. Patients were randomly assigned to a symptom-only monitored group and a group with therapy changes based on the symptoms and severity of AHR. Spirometry, exhaled nitric oxide, and blood eosinophils (BEos) were assessed on enrollment and every 3 months thereafter. RESULTS: During the study period, the number of mild exacerbations was lower in the AHR group (44 vs. 85; the absolute rate per patient 0.83 vs. 1.67; relative rate 0.49, 95% confidence interval: 0.346-0.717 (p < 0.001)]. Mean changes from baseline in clinical (except asthma control test), inflammatory, and lung function parameters were similar between groups. Baseline BEos correlated with AHR and was a risk factor for recurrent exacerbation in all patients. There was no significant difference in the final ICS dose between AHR and symptoms group: 287 (SD 255) vs. 243 (158) p = 0.092. CONCLUSIONS: Adding an indirect AHR test to clinical monitoring of childhood asthma reduced the number of mild exacerbations, with similar current clinical control and final ICS dose as in the symptom-monitored group. The hypertonic saline test appears to be a simple, cheap, and safe tool for monitoring the treatment of mild-to-moderate asthma in children.

Aerobic Capacity in Relation to Selected Elements of Body Posture.

BACKGROUND: In the 21st century, with the rapid development of many human life areas, physical activity should be prevalent in health maintenance and promotion. Body posture is a motor habit characteristic of every individual. Its correctness depends on numerous aspects, e.g., physical activity, age, mental state, or eating habits. There are numerous reports in the literature on the impact of physical activity on body posture, correct foot arch development, and the level of aerobic capacity in children and adolescents, but there is a noticeable lack of assessments of these characteristics and their correlations in adults. AIM: To evaluate aerobic capacity in males and females in relation to selected body posture elements. METHODS: The study involved 45 females and 46 males aged 20-21 years. The inclusion criteria involved declared good health and no contraindications. Selected somatic traits, body posture, and physical capacity indicators were determined. RESULTS: Physical capacity shows a significant relationship with body mass in both sexes (female: r = -0.346; p = 0.020; male: r = -0.321; p = 0.030). A significant correlation was observed between aerobic capacity and lean body mass in females (r = -0.428; p = 0.003) and body mass (r = -0.461; p = 0.001) and body fat percentage in males (r = -0.443; p = 0.002). A significant correlation was demonstrated between maximal oxygen uptake and Clarke's angle (r = -0.300; p = 0.045) in females, between maximal oxygen uptake and the loaded area of the right foot (r = -0.247; p = 0.098) in the male group, and between maximal oxygen uptake and spine lateral deviation (r = 0.352; p = 0.018) in females. There was no dimorphism between body posture elements and physical capacity except for the level of foot longitudinal arches, feet loading surface, spine lateral deviation, and the range of spine mobility in the sagittal and frontal planes. Aerobic capacity significantly influenced lean body mass (ß = -0.379; p = 0.007) and spine deviation from the anatomical axis in the frontal plane in females (ß = 0.287; p = 0.039) and body fat percentage in males (ß = -0.443; p = 0.002). CONCLUSIONS: Selected body posture elements demonstrate relationships with physical capacity in both sexes. The results should find wide practical applications, e.g., in promoting a comprehensive assessment of body posture and physical capacity as determinants of health maintenance.

Influence of the Weight of a School Backpack on Spinal Curvature in the Sagittal Plane of Seven-Year-Old Children.

UNLABELLED: The aim of the paper was to determine a correlation between the weight of a child's backpack, their body weight, and certain features of their body posture. MATERIAL AND METHODS: The study group consisted of 109 children, all aged seven years. The parameters of body posture were determined using the Zebris Ultrasonic System. RESULTS: The number of children carrying a school backpack in accordance with recommendations was 44 subjects (40.37%). Statistically significant changes were found in the total length of the spine (Z = 2.223, p = 0.026) and between backpack weight and changes in the following parameters: the total length of the spine (rs = -0.3999, p = 0.017), the length and the angle of the lumbar lordosis (rs = -0.3352, p = 0.049), the angle of the lumbar lordosis (rs = -0.5065, p = 0.002), and the sacral angle (rs = -0.4279, p = 0.010). CONCLUSIONS: Wearing a backpack heavier than 10% of one's body weight can cause shallowing of the lumbar lordosis and a tendency towards a vertical position of the sacrum. Monitoring the weight of children's school backpacks and enabling them to leave books and notebooks at school would probably be beneficial in reducing the daily burden put on children's spines.

Evaluation of factors influencing the quality and efficacy of ultrasound and phonophoresis treatment.

The first attempts at using ultrasound acoustic waves to aid the penetration of drugs into the skin tissue were made in the 1950's. Despite a wide usage of phonophoresis in physical therapy cabinets, doubts persist as to the relevance and efficacy of this method. Despite its popularity, the issue of conditions underlying the efficacy of phonophoresis treatment has still not been adequately addressed. Particular areas of interest include:1. treatment parameters to be followed in physical therapy. 2. appropriate dosage forms of drugs to ensure propagation of ultrasound waves 3. principles of omoeostasis and other physiological processes which play a decisive role in achieving the biological and therapeutic effects of ultrasound therapy.4. indications and contraindications to this kind of treatment The dearth of objective research methods and reliable scientific verification does not allow unambiguous determination of the efficacy of phonophoresis.