1.
J Am Chem Soc
; 125(44): 13481-5, 2003 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14583044
RESUMO
A new strategy for effecting cascade cyclization processes using nickel enolates has been developed. Nickel enolates may be cleanly generated by the oxidative cyclization of an enal and alkyne with Ni(0), and the resulting enolate may be functionalized by a variety of alkylation processes. Partially and fully intramolecular versions of the process allow the rapid synthesis of complex polycyclics from simple achiral, acyclic precursors.