[The characteristics of the effect of mediator substances on the dynamic oxygen tension in the gastric mucosa]. / Kharakteristika vliianiia mediatornykh veshchestv na dinamiku napriazheniia kisloroda v slizistoi obolochke zheludka.

The studies on rats were carried out to determine dynamics of pO2 in the mucous membrane of the stomach under the effect of acetylcholine, norepinephrine, serotonin, histamine, prostaglandin E2 and ATP. As to the changes in pO2 the mediator substances were arranged as follows (from more intensive effect to less pronounced one): serotonin, acetylcholine, prostaglandin E2, norepinephrine, histamine and ATP. As to the duration of the action--PGE2 acetylcholine, serotonin, norepinephrine, ATP and histamine. Under the joint action of the mediator substances (serotonin, norepinephrine, histamine) with acetylcholine the effects of domination and modulation of acetylcholine effect are found.

[The cytoprotective effect of prostaglandin E2 in duodenal ulcers]. / Tsitoprotektivnoe deistvie prostaglandina E2 pri iazvennoi bolezni.

Intragastric administration of a synthetic analog of prostaglandin E2 to patients with duodenal ulcers results in depression of the gastric acid production and in reduction of potassium level, leads to an elevation of the sialic acid debit and a rise of sodium concentration, not essentially changing calcium, chlorides, and pepsin levels. A combined analysis of gastric acid production and measurements of sialic acids, sodium and potassium detect the imbalance of the mucoid and bicarbonate secretion in peptic ulcers, this helping predict the disease course.

[Status of the electrolyte balance of the gastric juice during stimulation of secretion by histamine]. / Sostoianie élektrolitnogo balansa zheludochnogo soka pri stimuliatsii sekretsii gistaminom.

The content of electrolytes (Na+, K+, Ca2+) in human basal secrete has been determined before and after injection of histamine in gastric juice and insoluble mucus in healthy people. Electrolytes in the mucous membrane of the stomach, gastric juice and insoluble mucus have been determined in dogs with stomach fistula after Basow. Species peculiarities have been marked in electrolyte content change during gastric secretion.

[Characteristics of the combined effect of serotonin and histamine on the secretory function of the gastric glands]. / Osobennosti sovmestnogo vliianiia serotonina s gistaminom na sekretornuiu funktsiiu zheludochnykh zhelez.

The effect of serotonin, its combined effect with histamine on the gastric glands secretory function, and the morpho-functional condition of the mucous membrane of stomach were studied in dogs with the stomach fistula. The secretory response of gastric glands induced with histamine depended on the dose of serotonin. In combined action of serotonin and histamine, both the content of pepsin in gastric juice and the concentration of sodium and potassium ions increased.

[Effect of prostaglandin E2 on the secretory function of the stomach]. / Vliianie prostaglandina E2 na sekretornuiu funktsiiu zheludka.

The effect of prostaglandin E2 (PgE2) injected with histamine in dogs with stomach fistula, involved a decrease of volume of secreted gastric juice, production of hydrochloric acid and pepsin lessening as compared with the findings obtained in the effect of histamine alone. The inhibition of gastric secretion increases in combined injection of PgE2 with histamine and acetylcholine. After intramuscular injection of PgE2 the content of sodium ions in the blood serum of rats decreases, the concentration of potassium becoming higher. In the mucose membrane of stomach the content of sodium and potassium increases; oxygen pressure in the mucous membrane of stomach decreases after the injection of PgE2.

[Effect of acetylcholine on gastric secretory function and its vascular tonus]. / Vliianie atsetilkholina na sekretornuiu frnktsiiu zheludka i tonus ego sosudov.

Depending on doses, acetylcholine can produce the same effects in respect to activation of the stomach gland secretion either in hypodermic or intramuscular administration or acting from the surface of the stomach mucosa. Combination of acetylcholine and histamine produces the same secretory effect as food irritation. In acute experiments on dogs i.v. administration of acetylcholine causes a temporary contraction of vessels and a decrease of partial oxygen pressure, whereas in chronic experiments the same combination of the agents increases partial oxygen pressure which is suggestive of a decrease in the tone of stomach mucosa vessels.