[The effect of membrane-stabilizing and antioxidant preparations on the lipid peroxidation processes in cerebral stroke]. / Vplyv membranostabilizuiuchykh ta antyoksydantnykh preparativ na protsesy perekysnoho okyslennia lipidiv pry mozkovomu insul'ti.

Changes in the concentration of the lipid peroxidation products in the blood of 152 patients in stroke were studied. 18 patients with LPO processes activation received supplementary treatment with antioxidant preparation (tocopheroli acetas, ascorbic acid, pyridoxalphosphate, glutaminic acid), which lowered significantly the blood content of LPO products; in 12 patients with reduced concentration of LPO products treatments with membrane-stabilizing preparations (lipostabyl, sodium hydroxybutyrate, ascorbic acid, unithiol) were administered, and restoration of LPO processes was established to have occurred. With the purpose of improving methods and assessment of the cerebral insult treatment efficacy, it is recommended that specific features of changes in the concentration of LPO products be used.

[The characteristics of lipid peroxidation in patients with an acute disorder of the cerebral circulation]. / Osoblyvosti perekysnoho okyslennia lipidiv u khorykh z hostrym porushenniam mozkovoho krovoobihu.

A study is presented of 89 inpatients with cerebral stroke. Lipid peroxidation was determined during the first days of the diseases (1-7 days). The state of the patients was evaluated by the clinical picture, manifestation of neurological symptoms, biochemical indices of the blood, coagulogram, ECG, REG, state of lipid peroxidation. The obtained data suggest a major role played by lipid peroxidation of the cell membranes, its elevation in of the activity in stroke. The concentration of lipid peroxidation depends on the severity of the condition and, thus, it may be used for evaluation of treatment efficacy and prognosis of the disease.