Assuntos
Hemodinâmica , Hipertensão/fisiopatologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pletismografia de Impedância/métodos , Postura , Descanso , Fatores de TempoAssuntos
Doença de Hodgkin/patologia , Neoplasias Pulmonares/secundário , Adolescente , Criança , Ciclofosfamida/uso terapêutico , Quimioterapia Combinada , Doença de Hodgkin/tratamento farmacológico , Humanos , Neoplasias Pulmonares/diagnóstico , Masculino , Prednisolona/uso terapêutico , Procarbazina/uso terapêutico , Prognóstico , Vincristina/uso terapêuticoAssuntos
Doenças Biliares/cirurgia , Colangiografia/métodos , Ampola Hepatopancreática/cirurgia , Doenças Biliares/diagnóstico por imagem , Colecistectomia , Colecistite/cirurgia , Colelitíase/cirurgia , Colestase/cirurgia , Drenagem , Cálculos Biliares/cirurgia , Humanos , Avaliação de Processos e Resultados em Cuidados de Saúde , ReoperaçãoRESUMO
Plasma renin activity, aldosterone and cortisol levels, as well as renal blood flow were studied in borderline and established hypertensive patients and in healthy control subjects at rest and following graded dynamic upright exercise. Resting plasma renin activity was elevated in established hypertension, renal blood flow at rest was decreased in patients with borderline hypertension but its per cent decrease during exercise was similar in all groups. Following exercise, plasma renin activity increased in all groups but a step-wise increase with graded exercise occurred only in borderline hypertension. Resting plasma aldosterone and cortisol levels were similar in all groups. In the hypertension patients physical exercise was associated with disproportional changes of plasma renin activity and aldosterone levels. Plasma cortisol displayed patterns which were roughly similar to those or aldosterone in the control group an in established hypertension, but not in the borderline group, where the most pronounced increased of aldosterone level was associated with the lowest level of cortisol. It is concluded that the physiological response of the renin-angiotensin-aldosterone system to physical exercise is altered in essential hypertension.
Assuntos
Aldosterona/sangue , Hidrocortisona/sangue , Hipertensão/sangue , Esforço Físico , Renina/sangue , Adulto , Humanos , Masculino , DescansoRESUMO
The effect of physical exercise on plasma catecholamines and urinary catecholamines and metabolites was studied in 11 patients with established essential hypertension, 5 patients with borderline hypertension, and 9 healthy volunteers. Resting plasma noradrenaline and the changes following exercise were similar in all the investigated groups. Although the resting urinary noradrenaline excretion was similar in patients and in controls, an exaggerated increase of noradrenaline excretion occurred in hypertensive patients during physical work. This finding suggests sympathetic overreactivity in essential hypertension. The increased plasma levels of adrenaline, found in established hypertension, were associated with its diminished urinary clearance. These results imply altered renal handling of adrenaline in essential hypertension. Physical exercise was associated with enhancement of metabolism of noradrenaline to 3-methoxy,4-hydroxy-phenylglycol in all groups of subjects, but the stimulation of this pathway was particularly pronounced in healthy subjects. In essential hypertension, the pattern of urinary excretion of catecholamines and metabolites suggests impaired noradrenaline metabolism during exercise. The only characteristic feature of borderline, as opposed to established hypertension, was the increased urinary excretion of dopamine.
