RESUMO
The use and distribution of hazardous products in Danish industry were investigated. An exposure estimation model was developed. Based on data collected in the investigation and on the composition of about 9400 products national numbers of chemical exposure events and national volumes of chemicals were estimated. Data are presented for 36 chemical substances with chronic toxic effects and high estimated national numbers of exposure events. Seven of the 36 substances are carcinogens, 17 reprotoxicants, 12 allergens, and 18 neurotoxicants. This cross-sectional survey on chemical exposure may serve as comparison for future surveys.
Assuntos
Exposição Ocupacional/efeitos adversos , Alérgenos/efeitos adversos , Carcinógenos/efeitos adversos , Dinamarca , Humanos , Modelos Teóricos , Sistema Nervoso/efeitos dos fármacos , Reprodução/efeitos dos fármacos , Inquéritos e QuestionáriosRESUMO
Nation-wide incidence rates are presented of colorectal cancer in Denmark from 1943 to 1988. In Denmark notification of malignant and related diseases is mandatory. The percentage of histologically confirmed tumours is now 95. The annual incidence rate of colon cancer in Denmark has been increasing among men and women combined from 684 cases in 1943-1947 to 2020 cases in 1988. In the same period the incidence of rectal cancer has increased from 762 cases in 1943-1947 to 1108 cases in 1988. We analyzed the effects of age, calender time, and birth cohort with multiplicative Poisson models. We did not find consistent period effects in the models. We suggest an etiologic distinction between carcinoma of the rectum, the left colon and the right colon.
