Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: a review.

Lipophilicity properties have long been considered a vital component of drug discovery and development, providing insight into the role of molecular properties in the biological activity of known and new compounds. An extensive survey of the literature published in analytical and pharmaceutical chemistry journals has been conducted. Separation, optical, electrochemical and calculation methods which were developed and used for determination of lipophilicity non-steroidal anti-inflammatory agents and cephalosporin antibiotics in drugs and biological materials, have been reviewed. This review covers over 100 miscellaneous methods. Presented review highlighted some recent developments and new techniques that have been used in the lipophilicity detection of two different kinds of drugs.

[16-year experience with one-day surgery inguinal hernia repair]. / Leczenie przepuklin pachwinowych w systemie chirurgii jednego dnia na podstawie 16 lat wlasnych doswiadczen.

AIM OF THE STUDY: Evaluation of inguinal hernia repair techniques and results. MATERIAL: Study group consist of patients undergoing inguinal hernia repair between 1990-1998 326 patients (305 men, 21 women, mean age 45.5 yrs), and between 1999-2006 693 patients (662 men, 31 women, mean age 48.5 yrs). METHOD: Inguinal hernia repair techniques and anesthesia: 1990-1998: Bassini--234 (47.7%), Girard--52 (15.9%), Shouldice--36 (11.8%), PHS--2 (0.6%); general anesthesia--140 (430%), spinal anesthesia--186 (57%), 1999-2006: Lichtestein--207 (30.0%). Robbins-Rutkow--299 (43.1%), PHS--148 (21.3%), Shouldice--39 (5.6%); general anesthesia--28 (4%), spinal anesthesia--665 (96%). RESULTS AND CONCLUSION: 1. The use of synthetic mesh significant reduces inguinal hernia recurrences. 2. Returning to normal daily activities within short time after surgery. 3. The use of lowered doses of analgesics after surgery. 3. The use of lowered doses of analgesics after surgery. 4. After the use of synthetic hernia mesh the number of wound infections, hametaomas or seromas did not increase. 5. There were no differences in the intensity of postoperative pain related to synthetic mesh used. Inguinal hernia repair-management diagram. 1. Patients operated on through one-day surgery. 2. Hospital stay--12 hours. 3. Spinal anaesthesia. 4. The administration of antibiotic prophylaxis for elective inguinal hernia repair cannot be universally recommended. 5. We prefer Lichtenstein repair ("gold standard"). 6. Patient fully ambulated 4-6 hours after surgery. 7. Returning to normal daily activities after 2 weeks.

[Radiofrequency ablation of the primary and secondary liver malignancies]. / Zastosowanie termoablacji (RFA--radiofrequency thermal ablation) w leczeniu pierwotnych i wtórnych nowotworów zlosliwych watroby.

For primary liver tumors and selected cases of colorectal liver metastases, surgical resection with preserved oncological margins of healthy tissue has been a method of choice. The criteria that decide about qualifying the patients to surgical resections include the number of nodules, size, localization, infiltrations to vessels or neighboring organs, liver functions, and patient's general condition. In fact, these criteria confine the number of performed resections to 5-25% of cases. These low rates encourage the search for the effective methods of primary and secondary liver tumors destruction with low complication rates. The authors review the results of radiofrequency thermal ablation (RFA) used to treat hepatocellular carcinoma and colorectal metastases in 65 patients, who underwent 178 RFA procedures (143 percutaneous and 35 during laparotomy). Positive response (regression, fibrosis or stabilized disease) to RFA was obtained from 60% of cases, and 3 (1.7%) patients developed bowel perforation. RFA is recommended as effective method with low rates of complications to be used for palliative treatment of unresectable primary and secondary liver malignancies.

[Cryotherapy of liver tumors]. / Krioterapia guzów nowotworowych watroby.

AIM OF THE STUDY: To assess the value of cryodestruction during cytoreduction of liver tumors in the patients undergoing palliative treatment as well as evaluation of the frequency and type of complications of the method. PATIENTS AND METHOD: Between 1990-2001, 33 cryodestruction of maligant tumors of liver were performed for primary tumor in 8 cases and for metastatic lesions in 25. Thirteen patients had single, and the remaining 20 multiple lesions in liver. In 11 cases cryotherapy supplemented resective procedures or devascularisation of liver parenchyma. RESULTS: Mean time of follow-up was 14 months in the patients subjected to cryotherapy alone and 10 months in those subjected to cryotherapy as a supplementing modality. Postroperative complications related to cryotherapy did not exceed 9%, and overall mortality was 3%. CONCLUSIONS: Cryoablation is valuable alternative for other methods of palliative treatment in the patients with liver tumors.