[Prevention of reduced plasma fibronectin level in acute and chronic phenol and aniline poisoning in rats on vitamin-rich diet]. / Preduprezhdenie snizheniia v plazme krovi urovnia fibronektina pri ostroi i khronicheskoi intoksikatsii fenolom i anilinom u krys, puluchavshikh v ratsione povyshennoe soderzhanie vitaminov.

Plasma fibronectin, a glycoprotein having a great molecular weight and a quaternary structure is a specific animal protein that maintains the body's homeostasis on exposure to various adverse factors, such as mechanical, thermal or chemical injuries, infection, hemorrhage, intoxication or immune disease. In acute phenol intoxication, fibronectin levels were increased in rats up to 680 mg/l during 48 hours after the onset of priming and decreased up to 240 mg/l during the following 48 hours and then became stable. In acute aniline intoxication, fibronectin concentrations were decreased up to 120-130 mg/l during 4 days, later on its level became higher. The mechanisms responsible for the phenomenon are tentatively outlined. This is an acute phase process in the first case (phenol intoxication) and a stress process in the functioning of the reticuloendothelial system in the other case (aniline intoxication).

[Role of the vitamin factor in preventing phenol poisoning]. / Rol' vitaminnogo faktora v profilaktike intoksikatsii fenolom.

Experiments on rats were made to examine the effect of vitamin B1, pantothenic and ascorbic acids on the acetylation system and some characteristics of protein metabolism under chronic exposure to phenol. Inhibition of phenol vapours led to inhibition of the acetylation on the 105th day of the experiment, to accumulation of pyruvic acid by the blood and diurnal urine, to elevation of cholesterol content in the blood serum. The total content of protein and protein fractions in the blood serum remained unchanged. Additional vitaminization of the animals with thiamine (150 micrograms), calcium pantothenate (650 micrograms) or with their mixture containing ascorbic acid (2 mg) resulted in normalization of the test characteristics of carbohydrate and fat metabolism. The data obtained and the clinical trials carried out by the authors suggest introduction of the physiological doses of thiamine, calcium pantothenate and ascorbic acid into the diet of the workers in order to prevent phenol poisonings more effectively.

[Effect of a therapeutic and prophylactic diet enriched with thiamine and calcium pantothenate on the acetylating capacity of the body of workers engaged in the manufacture of phenol-formaldehyde resins]. / Vliianie lechebno-profilakticheskogo ratsiona, obogashchennogo tiaminom i pantotenatom kal'tsii, na atsetiliruiushchiu sposobnost' organizma rabochikh, zaniatykh v proizvodstve fenolformal'degidnykh smol.

The present investigation uncovered certain changes in the intensity of the acetylating processes, in the blood and urine levels of the pyruvic acid and in the urinary excretion of thiamine in a number of persons engaged in the production of phenol-formaldehyde resins. An enrichment of medico-prophylactic ration No 4 with thiamine and calcium pantothenate led to normalization of the study characteristics. The results thus made available bear proof to the prophylactic effectiveness of a supplementary vitaminization of the special diet accorded to workers handling phenol-formaldehyde resins.