RESUMO
Highly substituted, enantiomerically pure azaheterocyclic ring systems play an important role in medicinal chemistry as potential peptide mimetics. Metalated 2-alkenyl sulfoximines offer an efficient entry to this class of compounds. In this paper, we describe a new means to remove the sulfonimidoyl auxiliary with concomitant formation of a C-C double bond.
Assuntos
Carbono/química , Metionina Sulfoximina/análogos & derivados , Metionina Sulfoximina/química , Enxofre/químicaRESUMO
Gastrointestinal bleeding can be caused by a variety of pathologies. Primary aortoappendicular fistula is rare and, in our case, arose in addition to a chronic contained rupture sac of an abdominal aortic aneurysm. Clinical diagnosis is difficult. Aortic aneurysmorrhaphy along with extensive debridement and emphasis on antibiotic therapy is curative.
Assuntos
Aneurisma Infectado/complicações , Aneurisma da Aorta Abdominal/complicações , Doenças da Aorta/etiologia , Ruptura Aórtica/complicações , Apêndice , Fístula Intestinal/etiologia , Fístula Vascular/etiologia , Aneurisma Infectado/microbiologia , Aneurisma Infectado/cirurgia , Aneurisma da Aorta Abdominal/microbiologia , Aneurisma da Aorta Abdominal/cirurgia , Doenças da Aorta/cirurgia , Ruptura Aórtica/microbiologia , Ruptura Aórtica/cirurgia , Apendicectomia , Apêndice/microbiologia , Apêndice/cirurgia , Doenças do Ceco/etiologia , Doenças do Ceco/cirurgia , Doença Crônica , Humanos , Fístula Intestinal/cirurgia , Klebsiella pneumoniae/isolamento & purificação , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Fístula Vascular/cirurgia , Procedimentos Cirúrgicos VascularesRESUMO
The direct chromosome study of mitotic cells in effusions was performed in 49 patients with malignant and 5 with benign effusions. Cytogenetic analysis correctly identified 69.3% of malignant effusions, standard cytology 79.6%. With both methods combined 95.9% of all cases were correctly diagnosed as malignant. The presence of mitoses in the effusions was found to be an unfavorable prognostic sign and was correlated with a shorter survival. Chromosome analysis of the malignant effusions revealed stemlines with extensive numerical and structural rearrangements. No consistent marker chromosome was detected in the histologically similar tumor types. Normal chromosomes. No 1 and 14 were preferentially lost from the karyotype of malignant cells. In two samples double minutes were observed.
