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1.
Spinal Cord ; 54(12): 1183-1187, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27184917

RESUMO

STUDY DESIGN: Multi-center cross-sectional cohort study. OBJECTIVES: The objectives of this study were to develop and validate short forms (SFs) of participation for child- and parent-reported outcomes following spinal cord injury (SCI). SETTING: Three pediatric orthopedic hospitals in the United States. METHODS: The expert panel used calibration data from the pediatric computerized adaptive test (CAT) development study (convenience sample of 381 children and adolescents with SCI and 322 parents or caregivers) to select SF items. The panel selected items for two domains (participation self-relevant to what I want to do; participation friends-relevant to what my friends do), with parent and child versions for each domain. Psychometric analyses included group reliability, Cronbach's alpha, agreement (SFs and item banks), percent of sample with highest (ceiling) and lowest (floor) scores by level of lesion (paraplegia/tetraplegia), and test information function. RESULTS: Group reliability and Cronbach's alpha values are acceptable (0.74-0.92) and agreement (intraclass correlation coefficients for SFs and total item banks) is strong (0.89-0.95). Floor effects were minimal for people with tetraplegia and paraplegia (0-1.19%). Ceiling effects were minimal for people with tetraplegia (0-3.13%) and slightly higher, but acceptable, for people with paraplegia (8.06-14.02%). Test information function for the SFs was sufficiently high over the range of scores for the majority of the sample. CONCLUSION: Pediatric Measure of Participation (PMoP) SFs are acceptable for use when CATs are not feasible. SPONSORSHIP: The study was funded by the Shriners Hospitals for Children Research Grant 79142 (Mulcahey, PI) and the Boston ROC Grant 5R24HD065688-05 (Jette, PI).


Assuntos
Participação do Paciente/métodos , Traumatismos da Medula Espinal/terapia , Adolescente , Calibragem , Estudos Transversais , Estudos de Viabilidade , Feminino , Amigos , Hospitais Pediátricos , Humanos , Masculino , Paralisia/complicações , Paralisia/diagnóstico , Paralisia/psicologia , Paralisia/terapia , Pais , Psicometria , Autorrelato , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/diagnóstico , Traumatismos da Medula Espinal/psicologia , Resultado do Tratamento , Estados Unidos
2.
Spinal Cord ; 54(7): 546-52, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26572606

RESUMO

STUDY DESIGN: A cross-sectional study. OBJECTIVES: The Pediatric Spinal Cord Injury Activity Measure (PEDI-SCI AM), which includes calibrated item banks (child and parent versions) for general mobility, daily routines, wheeled mobility and ambulation, can be administered using computerized adaptive tests (CATs) or short forms (SFs). The study objectives are as follows: (1) to examine the psychometric properties of the PEDI-SCI AM item banks and 10-item CATs; and (2) to develop and evaluate the psychometric properties of PEDI-SCI AM SFs. SETTING: US Shriners Hospitals for Children (California, Illinois and Pennsylvania). METHODS: Calibration data from a convenience sample of 381 children and adolescents with SCI and 322 parents or caregivers were used to examine PEDI-SCI AM item banks, 10-item CATs and SF scores. We calculated group reliability, internal consistency (Cronbach's alpha) and interclass coefficients (ICCs) to assess agreement between 10-item CATs, SFs and item banks. The percent of the sample with highest (ceiling) and lowest (floor) scores was also determined. An expert panel selected items for 14 SFs. RESULTS: PEDI-SCI item banks, 10-item CATs and SFs demonstrate acceptable group reliability (0.73-0.96) and internal consistency (0.77-0.98). ICC values show strong agreement with item banks for 10-item CATs (0.72-0.99) and SFs. Floor effects are minimal (<15%). Ceiling effects are minimal for children with tetraplegia but high in children with paraplegia for general mobility (13.41-26.05%) and daily activities (12.99-32.71%). CONCLUSIONS: The PEDI-SCI AM exhibited strong psychometric properties for children with tetraplegia. Replenishment of the general mobility and daily routine item banks is needed to reduce ceiling effects noted for youth with paraplegia.


Assuntos
Avaliação de Resultados em Cuidados de Saúde , Traumatismos da Medula Espinal , Atividades Cotidianas , Adolescente , Algoritmos , Criança , Avaliação da Deficiência , Feminino , Humanos , Masculino , Paraplegia/reabilitação , Psicometria , Reprodutibilidade dos Testes , Traumatismos da Medula Espinal/fisiopatologia , Traumatismos da Medula Espinal/psicologia , Traumatismos da Medula Espinal/reabilitação , Inquéritos e Questionários , Índices de Gravidade do Trauma , Adulto Jovem
3.
Spinal Cord ; 48(3): 262-7, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19841635

RESUMO

STUDY DESIGN: This study used qualitative analysis of focus group discussions. OBJECTIVE: The primary objective was to select functional activities to include in an item pool, which is the first step in developing a spinal cord injury computer adaptive test (SCI-CAT). SETTING: This multisite study was conducted at six US National Spinal Cord Injury Model Systems Programs. METHODS: Focus group discussions, which included persons with tetraplegia and paraplegia and clinicians, were conducted. Transcripts were analyzed using a grounded theory approach. Functional activities were identified, binned, winnowed, written as functional items, and cognitively tested. RESULTS: Focus group discussion analysis identified 326 functional activity items that fit into categories outlined in the International Classification of Functioning, Disability and Health (ICF) framework: Mobility (193 items), including assessment of functioning in a manual (44 items) and power wheelchair (19 items); self-care (109 items); and communication (19 items). Items related to sexual function were also identified (5 items). CONCLUSION: The SCI-CAT item pool includes items that assess functional activities important to persons with SCI. Items cover a wide range of functional ability and reflect most ICF categories. The SCI-CAT pool is currently being field tested to develop a calibrated item bank. Further development will yield a CAT of functional activities appropriate for SCI research.


Assuntos
Recuperação de Função Fisiológica/fisiologia , Traumatismos da Medula Espinal/diagnóstico , Traumatismos da Medula Espinal/reabilitação , Atividades Cotidianas , Adulto , Efeitos Psicossociais da Doença , Muletas , Avaliação da Deficiência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Limitação da Mobilidade , Destreza Motora , Movimento/fisiologia , Paraplegia/diagnóstico , Paraplegia/reabilitação , Quadriplegia/diagnóstico , Quadriplegia/reabilitação , Padrões de Referência , Autocuidado , Disfunções Sexuais Fisiológicas/epidemiologia , Traumatismos da Medula Espinal/complicações , Resultado do Tratamento , Andadores , Caminhada/fisiologia , Cadeiras de Rodas
4.
Phys Ther ; 79(7): 672-81, 1999 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10416576

RESUMO

BACKGROUND AND PURPOSE: The purpose of this study was to determine the level of muscle force associated with ability to walk in the community without assistance, in the community with assistance, or at home only in individuals with amyotrophic lateral sclerosis (ALS). SUBJECTS AND METHODS: Percentage of predicted maximal muscle force (%PMF) of lower-extremity muscles was determined, and walking ability was categorized in 118 patients with ALS during periodic visits to the Neuromuscular Research Unit. Data were derived from consecutive visits in which subjects demonstrated declines in walking ability. Means for %PMF of each muscle group and a limb average were calculated at each consecutive visit. RESULTS: The mean lower-extremity average %PMF was: (1) 54.01% (SD=12.76%) for subjects who walked independently in the community and 50.19% (SD=14.38%) during the next visit when these same subjects required assistance in the community (difference=3.82%, 95% confidence interval [CI]= 2.45-5.19);(2) 37.52% (SD=15.17%) during the last visit that subjects walked with assistance in the community and 32.18% (SD=13.83%) during the next visit when they walked only at home (difference=5.33%, 95% CI=3.61-7.06); and (3) 19.12% (SD=9.08%) during the visit when subjects were last able to ambulate at home versus 13.70% (SD=7.36%) when they became unable to walk (difference=5.42%, 95% CI=2.97-7.96). CONCLUSION AND DISCUSSION: The findings suggest there are required levels of lower-extremity muscle force for various categories of walking ability. Variations in forces within and between categories of walking ability, however, indicate the complexity of this relationship.


Assuntos
Esclerose Lateral Amiotrófica/reabilitação , Avaliação da Deficiência , Contração Isométrica/fisiologia , Perna (Membro)/fisiologia , Caminhada/fisiologia , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
5.
Arch Phys Med Rehabil ; 79(8): 950-4, 1998 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9710168

RESUMO

OBJECTIVE: To examine the relation between lower extremity muscle force production and functional ambulation in patients with amyotrophic lateral sclerosis (ALS). DESIGN: Retrospective analysis of data collected from 1979 to 1995. PATIENTS: Two hundred forty ALS patients referred to the New England Medical Center Neuromuscular Research Unit. MAIN OUTCOME MEASURES: Muscle force production during a maximum, voluntary isometric contraction of ankle dorsiflexors, knee flexors, knee extensors, hip flexors, and hip extensors was calculated as percent predicted maximal force (PPMF). Functional ambulation status was classified as unable, home, or community. RESULTS: The probability of community ambulation compared with home increased with progressively higher PPMF for all muscle groups. Subjects with knee flexion strength greater than 75% PPMF were 395 times more likely to ambulate in the community. Subjects with hip extension strength over 50% PPMF showed improved chance of ambulation at home. CONCLUSION: Lower extremity PPMF is a critical factor determining functional ambulation in patients with ALS. Knee flexors play an important role in community ambulation while the hip extensors are important for home ambulation.


Assuntos
Atividades Cotidianas , Esclerose Lateral Amiotrófica/fisiopatologia , Marcha/fisiologia , Contração Isométrica/fisiologia , Perna (Membro)/fisiopatologia , Caminhada/fisiologia , Esclerose Lateral Amiotrófica/reabilitação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Valor Preditivo dos Testes , Amplitude de Movimento Articular , Estudos Retrospectivos
7.
Science ; 225(4659): 340-2, 1984 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-6740316

RESUMO

Adult rats with bilateral lesions of the caudate nucleus were treated with GM1 ganglioside. Although animals injected with a control solution were severely impaired in their ability to learn a complex spatial task, those treated with ganglioside were able to learn spatial reversals.


Assuntos
Comportamento Animal/efeitos dos fármacos , Lesões Encefálicas/tratamento farmacológico , Gangliosídeo G(M1)/uso terapêutico , Gangliosídeos/uso terapêutico , Animais , Lesões Encefálicas/psicologia , Núcleo Caudado/efeitos dos fármacos , Núcleo Caudado/lesões , Gangliosídeo G(M1)/farmacologia , Humanos , Aprendizagem/efeitos dos fármacos , Masculino , Ratos , Ratos Endogâmicos
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