RESUMO
Sex differences in the expression of iodide transporter SLC5A5 and thyroid peroxidase in thyroid follicular epithelium and thyroid serum profile were assessed in pubertal rats exposed to endocrine disruptor DDT starting from the first postnatal day. It was found that exposure to DDT reduced expression of SLC5A5 in peripheral regions of thyroid lobes in males and in central regions in females. The most pronounced sex differences were observed in thyroid peroxidase expression that remained sensitive to thyroid stimulating hormone regulation in males and lost sensitivity to pituitary stimulation in females after exposure to disruptor, which determines more pronounced hypothyroidism in females.
Assuntos
DDT/farmacologia , Disruptores Endócrinos/farmacologia , Regulação da Expressão Gênica/efeitos dos fármacos , Hipotireoidismo/genética , Glândula Tireoide/efeitos dos fármacos , Animais , Animais Recém-Nascidos , Feminino , Hipotireoidismo/induzido quimicamente , Hipotireoidismo/metabolismo , Hipotireoidismo/patologia , Iodeto Peroxidase/genética , Iodeto Peroxidase/metabolismo , Masculino , Ratos , Ratos Wistar , Receptores da Tireotropina/genética , Receptores da Tireotropina/metabolismo , Fatores Sexuais , Maturidade Sexual , Simportadores/genética , Simportadores/metabolismo , Glândula Tireoide/metabolismo , Glândula Tireoide/patologia , Tireotropina/genética , Tireotropina/metabolismo , Tiroxina/genética , Tiroxina/metabolismo , Tri-Iodotironina/genética , Tri-Iodotironina/metabolismoRESUMO
Consumption of low dose DDT from birth until puberty suppressed functional activity of the thyroid gland in rats and leads to destructive changes in the organ during the postpubertal period with compensatory stimulation of secretory activity of thyrocytes aimed at normalization of thyroxin production.
