[Spheroid formation in explants of human breast tumor and fibroadenomatous tissues and lymphoid infiltration of explants during cultivation in diffusion chambers]. / Obrazovanie sferoidov v éksplantatakh opukholevoi i fibroadenomatoznoi tkanei molochnoi zhelezy cheloveka i limfoidnaia infil'tratsiia éksplantatov pri ikh kul'tivirovanii v diffuzionnykh kamerakh.

An extensive formation of epithelioid cell spheroids was shown during tumour tissue growth on millipore filters. In addition, the appearance of such multicellular structures as an early sign of malignant transformation was demonstrated in some fibroadenomatous tissue cultures. The increased fibroadenomatous tissue proliferative activity was accompanied by the rising level of lymphoid cell infiltration.

[Functional and histochemical parameters of the neutrophil state in patients with malignant tumors]. / Funktsional'nye i gistokhimicheskie parametry otsenki sostoianiia neitrofilov bol'nykh so zlokachestvennymi novoobrazovaniiami.

A functional state of neutrophils was studied by their ability to chemotaxis and phagocytosis as well as their enzymatic activity (myeloperoxidase, acid and alkaline phosphatase, glycogen, cation proteins) of 13 patients with malignant neoplasms in dynamics (before and 2 weeks after the radical operation) was studied. Decreasing of all investigated parameters before the operation and significant increasing of chemotaxis and phagocytosis after the operation were revealed.

[Proliferative activity of cells in dyshormonal fibroadenomatosis of the human breast]. / Proliferativnaia aktivnost' kletok pri disgormonal'nom fibroadenomatoze molochnoi zhelezy cheloveka.

Fibroadenomatous tissue of the human mammary gland was cultivated in diffuse chambers implanted into mice. On day 6 of culture the growing cells were subjected to morphological and autoradiographic analysis. The index of 3H-thymidine labeling of cell nuclei was found to correlate with the morphological pattern of dyshormonal fibroadenomatosis of the mammary gland. It is discussed whether it is desirable to use the culture in diffuse chambers for screening the actively proliferating forms human mammary gland dyshormonal dysplasias prone to malignancy.

[Polyamine excretion in patients with tumors]. / Ekskretsiia poliaminov u bol'nykh opukholiami

Polyamines excretion with the urine in patients with cancer of the stomach, lung, mammary gland and cervical cancer is considerably increased, as compared with patients having nontumor lesions and healthy individuals. Following a surgical removal of the tumor as well as after chemotherapy the level of polyamines in the diurnal urine is diminished up to normal values. The determination of polyamines excretion may serve as a test for laboratory diagnosis of malignant tumors and also as a criterion of the efficacy of treatment.