THE STUDY OF ACTION THE OZONE IN THE SURGICAL TREATMENT OF INFLAMMATORY PROCESSES BY DIABETES MELLITUS.

OBJECTIVE: The aim: was to improve the course of purulent wounds in diabetes by using physical therapies. PATIENTS AND METHODS: Materials and methods: we investigated 122 patients with diabetes mellitus and wound processes. We divided all patients on the two groups. Our study groups were 50 patients who had therapy by ozone together with other general treatment and surgery treatment (daily dressings, ointments and solutions). Our control groups were 72 patients, who had treated only by general methods and surgery treatment (daily dressings, ointments and solutions).The patients of our explore group had received intravenous injection of saline ozone solution together with other general treatment and surgery treatment (daily dressings, ointments and solutions). RESULTS: Results: it had studied of indicators of oxidative modification of proteins, lipid peroxidation in blood plasma, antioxidant protection during this period, there were no significant changes in these parameters between the control and experimental groups. As the result of the study was found that the leukocyte index of intoxication in patients in the main and control groups was almost indistinguishable. Regarding the indexes of hematological index of intoxication, which decreased during the treatment of patients of the main group, and different from the patients of the control group, in which this indicator increased sharply. The result of the study of changes in the indicators of sorption capacity of erythrocytes showed that the level of sorption capacity of erythrocytes in patients in the main group during treatment, also decreased, compared with patients in the control group. CONCLUSION: Conclusions: Therefore, the use of ozone in the treatment of patients with complicated forms of diabetes does not cause a negative impact on the dynamics of homeostasis and indicators of the level of intoxication of the body. Ozone therapy has a beneficial effect on the course and wound process in patients with diabetes with purulent processes.

The level of some hormones in the blood women with endometriosis which associated with infertility.

OBJECTIVE: Introduction: The work has been dedicated the study of pituitary hormone concentration in the blood of women with endometriosis-associated infertility on 2-3 days of the menstrual cycle and the day of the puncture of ovarian stimulation superovulation in the cycle. The aim of our study was to examine the concentration of pituitary hormones in the blood of women with endometriosis associated with infertility. PATIENTS AND METHODS: Materials and methods: For the purpose of the research we have conducted a special study of protein (lutropin - LH, folitropin -FSH) hormones level in the blood plasma of women with endometriosis associated with infertility, which formed the main group of 20 people. Similar studies of protein hormones level were performed in the control group, which made somatically healthy women of reproductive function preserved, whose age corresponded to the age of patients of the main group. The value of p (authenticity difference) was determined by Student's table-Fischer. Differences between contrasting averages were considered significant at p <0.05. RESULTS: Results and conclusions: Analized the results of our research stated that women with endometriosis associated with infertility 2-3 days of the menstrual cycle endocrine function of gonadotropocites anterior pituitary did not differ from that of the control group. This fact appeared to have an additional criteria for the formation of a main group. In patients with endometriosis associated with infertility found significant violation of rhythm and secretion of blood gonadotropin hormones that are proportionate to the degree of severity of the disease.

Peculiairities of the functioning circadian organization the ion-regulating function of kidney under the condition of pineal gland hyperfunction of the influence nitrogen monoxide synthesis blockade.

OBJECTIVE: The aim of our work was to investigate the peculiarities of the functioning circadian organization the ion-regulating function of pineal gland hyperfunction of the influence nitrogen monoxide synthesis blockade. PATIENTS AND METHODS: Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The control group included animals (n=36) kept under conditions of usual light regimen (12.00L:12.00D) during 7 days. The experimental group included animals (n=36) injected with N-nitro-L-arginine (L-NNA) in the dose of 20 mg/kg during 7 days under conditions of continuous absolute darkness (12.00D:12.00D). On the 8th day the animals were exposed to 5% water load with heated to room temperature water supplied and the parameters of the kidney ion-regulating function under conditions of forced diuresis were investigated. RESULTS: Results and conclusions: The obtained results of the performed blockade nitrogen monoxide (NO) synthesis in conditions of hyperfunction of the brain epiphysis allow to conclude that the daily mean of the rate of excretion of sodium ions decreases in comparison with the animals that were kept under pineal gland (PG) hyperfunction of the filtration fraction and reabsorption of sodium ions are reduced compared to the control animals and rats which were kept under conditions of PG hyperfunction and accompanied by stable indicators of the concentration the specified cation in the blood plasma during the observation period. The action of the blockade NO synthesis in conditions of PG hyperfunction leads to a decrease in the distal transport bridge of sodium ions with a maximum in the day and night intervals of the day the position of the acro- and batiphase of the rhythm changes as compared with the control animals.

Influence of variants circadian rhythm of blood pressure on the functional state of the cardiovascular system in patients with essential hypertension II degree.

OBJECTIVE: Introduction: Blood pressure is chronic disease in which the main diagnostic feature (symptom) is a persistent increase in hydraulic pressure in the arterial vessels of the large circulatory system. Increased blood pressure causes the heart to work with greater load due to increased general peripheral vascular resistance to ensure normal blood circulation in the blood vessels of the large circulatory system. The aim of our work was to detection of features of the functional state of the cardiovascular system in patients with essential hypertension II degree depending from the circadian structure of blood pressure. PATIENTS AND METHODS: Materials and methods: The complex examination of 62 patients with essential hypertension II degree with II-III degree by increase of blood pressure. The average age of patients was - 56.2 ± 2.1 years. There were examined the 36 men and 26 women. All 62 patients with essential hypertension of IInd stage with II-III degree of blood pressure increase were divided into 3 groups due to the circadian structure of blood pressure: « Dipper¼ -26; «Non dipper¼-28; and «Night picker¼ -8. RESULTS: Results and conclusions: In patients with the daily index "Dipper" the normokinetic range of hemodynamics prevails, make a difference to patients with "Non dipper" and "Night picker", which has a mainly hypokinetic range of hemodynamics, which is confirmed by ratios of indicators to the area and weight of the body of the subjects. In addition to holding parallels between the body mass index and the left ventricular mass index enables that the increase in inconsistency of the body mass index to the left ventricular myocardial mass index, which deepens in groups from "Dipper" to "Night Picker", can increase the metabolic imbalance of the myocardium.

Circadian characteristic of kidney excretory function influenced by nitrogen monoxide synthesis blockade under conditions of pineal gland normal with peculiarities of melatonin effect.

OBJECTIVE: The features of сhronorhythmic alterations of excretory renal function under the physiological conditions of the pineal gland (PG) under the influence of a blockade of synthesis of nitrogen monoxide (NO) and melatonin correction were investigated. The aim: Aim of our work was to investigate circadian characteristic of kidney excretory function influenced by nitrogen monoxide synthesis blockade under conditions of pineal gland normal with peguliarities of melatonin effect. PATIENTS AND METHODS: Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The animals were kept under vivarium conditions at a stable temperature and air humidity fed on a standard dietary intake. RESULTS: Results and conclusions: Based on a series of studies, the blockade of NO synthesis and melatonin correction resulted in a decrease in the average daily urinary output and a decrease in the removal of potassium ions from urine, relative to control, during the observation period. Therefore, the clarification of the features of сhronorhythmic alterations of the excretory renal function under the physiological conditions of the PG under the influence of blockade of NO synthesis and melatonin correction is important for the knowledge of the mechanisms of occurrence and development of pathological conditions, which will enable to improve the early diagnosis, improve the treatment of renal pathology and timely preventative measures.

Application of ozone therapy in surgical practice.

Summarizing the review of literary sources, one can conclude that, despite a significant number of scientific papers devoted to the problem of pyoinflammatory complications of diabetes, there remain issues that require further study and solution. Taking into account the above facts, it becomes obvious that it is necessary to seek for more effective and advanced methods of complex treatment of pyoinflammatory complications of soft tissues, with an emphasis of search efforts on the introduction of effective therapeutic methods of conservative correction into the medical practice, methods of activation of reparative processes, aimed at restriction of invalidizating limb amputations, combined with further improvement of minimally invasive operational and technical innovations in the surgical direction.

Obstetric and gynecological care by family doctors in ukraine: literature review.

OBJECTIVE: Introduction: The analysis of literature on the questions of obstetrical and gynecologic care by general practitioners - family doctors in Ukraine has been presented in the article. Special attention has been paid to the actual problems of primary health care implementation on the basis of family medicine. The aim of the study is to find out the depth of the problem "A female doctor as an obstetrician-gynecologist" by analyzing scientific relevant literature data. PATIENTS AND METHODS: Materials and methods: An analysis of international and national scientific literature on the problem of obstetrical and gynecologic care by general practitioners - family doctors. CONCLUSION: Conclusions: It is evident from the review of negative demographic situation that at present topical are the issues of extension of primary care professionals' functions concerning sexual upbringing, family planning, reproductive health promotion of the population, improvement of the qualification level of doctors on obstetricgynecological assistance issues and creation of a motivation system for primary care physicians, which requires a decision at the national level.

Peculiairities of the influence nitrogen monoxide synthesis blockade on circadian organization of kidney acid-regulating function under conditions of pineal gland hyperfunction.

OBJECTIVE: Introduction: In recent decades chronobiology - a science that studies the regularities of the functioning of the organism, especially biological rhythms is developing rapidly. Biorhythms are stable nonstopper lifetime fluctuations with individual amplitude-frequency characteristics. Kidneys are characterized by a clear time organization of functions too, however, the peculiarities of circadian organization and the mechanisms of the participation of intracellular messengers in particular nitrogen monoxide (NО) in biorhythmic regulation of renal functions, remain insufficiently studied The aim of our work was to investigate the peculiairities of the influence nitrogen monoxide synthesis blockade on circadian organization of kidney acid-regulating function under conditions of pineal gland hyperfunction. PATIENTS AND METHODS: Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The animals were kept under vivarium conditions at a stable temperature and air humidity fed on a standard dietary intake. The control group included animals (n=36) kept under conditions of usual light regimen (12.00L:12.00D) during 7 days. The experimental group included animals (n=36) injected with N-nitro-L-arginine (L-NNA) in the dose of 20 mg/kg during 7 days under conditions of continuous absolute darkness (12.00D:12.00D). On the 8th day the animals were exposed to 5& water load with heated to room temperature water supplied and the parameters of the kidney acid-regulating function under conditions of forced diuresis were investigated. RESULTS: Results: The inhibition of the monoxide synthesis (NО) in conditions of pineal gland (PG) hyperfunction violated the structures of chronorhythms acid-regulating function of the kidneys. The decrease in urine pH at daytime intervals was due to a decrease in the level of hydrogen ion excretion during this period of the day. The introduction of the NО blocker against the background of the PG hyperfunction violated the structure of the acid esterification chronorhythms that are titrated. The maximum level of this indicator was recorded at 20.00 a.m. a day. The blockade of the synthesis NО on the background of the PG hyperfunction significantly reduced the level of excretion of ammonia. CONCLUSION: Conclusions: The maximum level of excretion was 12.00 a.m., bathyphase - at 24.00 a.m. The average daily level was 1.5 mcmol/100 mcl GF and was lower relative to the control animals and animals that were in the conditions of PG hyperfunction.