RESUMO
The article presents new approach to treatment of radiation disorders presenting as indolent ulcers. The approach is based on autologous multipotent mesenchimal stromal cells applied locally and injected around the injuried zone. The ulcers heal due to the fact that the transplanted cells stimulate local regeneration processes, angiogenesis, ceased inflammation and apoptosis. The method is a new medical technology based on vast preclinical studies and could be put into medical practice.
Assuntos
Raios gama/efeitos adversos , Transplante de Células-Tronco Mesenquimais/métodos , Células-Tronco Multipotentes/transplante , Radiodermite , Úlcera Cutânea/terapia , Idoso , Resistência a Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neovascularização Fisiológica , Doses de Radiação , Radiodermite/fisiopatologia , Radiodermite/terapia , Regeneração , Índice de Gravidade de Doença , Pele/efeitos da radiação , Úlcera Cutânea/etiologia , Úlcera Cutânea/fisiopatologia , Terapias em Estudo/métodos , Transplante Autólogo/métodos , Resultado do TratamentoRESUMO
Transplantation of mesenchymal stem cells (MSCs), at early and later stages after local exposure of rats to 140 Gy 90Sr/90Y beta radiation, was found to stimulate recovery of damaged skin. The area of local radiation injuries (LRIs) and accelerated healing of radiation ulcers was obtained. Clinical evolution showed the high efficiency of the transplantations of autologous MSCs for the treatment of deep beam ulcers, usually refractive to standard conservative treatment. Analogous to our results in the rats the authors obtained promising results with the application of MSCs for the treatment of severe LRIs in two human patients. Their radiation ulcers showed complete healing after stem cell application. Thus, further developments should determine the best possible conditions for MSC use in LRI treatment.
Assuntos
Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais , Animais , Partículas beta , Humanos , Ratos , CicatrizaçãoRESUMO
Transplantation of mesenchymal stem cells, both at early and later stage after local exposure of rats source beta radiation dose, 90Sr/90Y 140 GR, stimulates recovery of damaged skin. Diminution area local radiation injuries and accelerate healing radiation ulcers. Clinically shows the high efficiency of the transplantations autologous mesenchymal stem cells in treatment of deep beam ulcers, intractable standard conservative treatment. Found promising application of mesenchymal stem cells for treatment of severe local radiation injuries and the need to develop the best possible conditions for their use.
