[The liver-protective properties of the pediatric drug form of propolis in animals of different age groups]. / Izuchenie gepatozashchitnykh svoistv detskoi lekarstvennoi formy propolisa u zhivotnykh raznykh vozrastnykh grupp.

The pharmacological activity of a pediatric formulation of the phenolic hydrophobic drug propolis was studied in the experiments on albino rats of various age with toxic liver damages of various duration and in acute hepatic ischemia. In all models of hepatic abnormalities, the drug was found to show antioxidative properties which were moderate (30-60%). In addition, there were improvements in hepatic secretion of bile, cholic acids, and cholesterol. On the other hand, the membrane-stabilizing effect of the drug was exerted in not all the tested models of hepatic damage.

[The efficacy of hydroxycinnamic acids in toxic lesions of the liver]. / Effektivnost' oksikorichnykh kislot pri toksicheskikh porazheniiakh pecheni.

The albino rat experiments studied the pharmacological action of oxycinnamic acid derivatives in acute tetrachloromethane-induced hepatic dystrophy and combined CCl4-ethanol-induced hepatic lesion. The tested agents were found to produce cholagogic, membrane-protective, and antioxidative effects in these hepatic abnormalities, thus improving the functional (cholate- and glycogen-synthetic) parameters of the liver.

[Hepatoprotective activity of analogs of cinnamic acid]. / Gepatozashchitnaia aktivnost' analogov korichnoi kisloty.

The hepatoprotective activity of 16 derivatives of +hydroxycinnamic acids was studied on the model of acute tetrachloromethane-induced hepatitis. The effects of the agents administered in doses of 5, 15, and 30 mg/kg were compared with those of silibor, vitamin E and flamine. The studied compounds were shown to possess the bile-expelling, antioxidant and membrane-protective effects being superior in some cases to similar effects of reference drugs. The structure-activity relationship was established.