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Biotechnol Annu Rev ; 10: 237-50, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15504708

RESUMO

Anti-erythropoietin (EPO)-induced pure red cell aplasia (PRCA) is an uncommon, potentially life-threatening condition in which the bone marrow stops manufacturing red blood cells. In the past few years, reports of drug-induced, anti-EPO antibody-mediated PRCA have increased substantially, with most cases attributed to the use of one erythropoiesis-stimulating protein, Eprex. A literature review was undertaken to document the reports of drug-induced PRCA, with all drugs and drug regimens. The sudden increase in reports of antibody-mediated PRCA is discussed.


Assuntos
Anticorpos/imunologia , Ensaios Clínicos como Assunto , Eritropoetina/efeitos adversos , Aplasia Pura de Série Vermelha/induzido quimicamente , Aplasia Pura de Série Vermelha/imunologia , Eritropoetina/uso terapêutico , Humanos , Fatores Imunológicos/imunologia , Proteínas Recombinantes
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