Safety of dry needling in stroke patients: a scoping review.

INTRODUCTION: Spasticity is a common problem in stroke patients. Treatments of spasticity often have side effects or are insufficiently effective. Dry needling (DN) has been proposed as a potential additional option to consider in the multimodal treatment of post-stroke spasticity, although questions about its safety remain. The goal of this study is to assess the safety of DN in stroke patients. EVIDENCE ACQUISITION: A systematic search in Medline, Embase, The Cochrane Library, Web of Science, CIHNAL and PEDro was conducted in June 2023. Two reviewers independently screened abstracts according to the eligibility criteria. EVIDENCE SYNTHESIS: Twenty-five articles were included in this review. Only six studies reported adverse events, all of which were considered minor. None of the included studies reported any serious adverse events. In four of the included studies anticoagulants were regarded as contra-indicative for DN. Anticoagulants were not mentioned in the other included studies. CONCLUSIONS: There is a paucity of literature concerning the safety of DN in stroke patients. This review is the first to investigate the safety of DN in stroke patients and based on the results there is insufficient evidence regarding the safety of DN in stroke patients. CLINICAL REHABILITATION IMPACT: Although DN could be a promising treatment in post-stroke spasticity, further research is indicated to investigate its mechanism of action and its effect on outcome. However, before conducting large clinical trials to assess outcome parameters, the safety of DN in stroke patients must be further investigated.

Comparison of immediate versus optional delayed surgical repair for treatment of acute anterior cruciate ligament injury through a parallel, multicentric, pragmatic randomized controlled trial - IODA trial.

BACKGROUND: Standard care for anterior cruciate ligament (ACL) injuries often includes surgical reconstruction of the ACL. However, two randomized controlled trials [1, 2] (RCT) concluded that conservative treatment does not result in inferior clinical outcomes compared to immediate ACL reconstruction. More research is needed to verify these results and assess whether patient-specific parameters determine if a patient would benefit from one treatment option over the other. METHODS: This is a pragmatic, multi-center RCT with two parallel groups. Patients with an acute ACL injury will be recruited from Belgian hospitals. Patients will be randomized to conservative treatment (rehabilitation + optional delayed surgery) or immediate ACL reconstruction (< 12 weeks). The primary outcome is the Knee injury and Osteoarthritis Outcome Score (KOOS) at 7 months (short term) and 1-year long term) post-injury. These following additional outcomes will be administered at 4 and 7 months (short term) and 1, 2, and 3 years post-injury (long term): patient-reported outcomes concerning knee symptoms, knee function and quality of life, functional knee tests, time to return to pre-injury activity level and return to work, structural knee joint damage and cartilage health (only at 4 months and 3 years post-injury), as well as adverse events such as re-rupture rates. Furthermore, the secondary objective is to identify (through a predictive analysis) individuals who would benefit the most from early reconstruction versus those who should rather be treated conservatively. DISCUSSION: This large RCT will assess the clinical effectiveness of both surgical and conservative treatment. In addition, it will be the first study that provides insights into which patient-specific factors predict successful outcomes after conservative treatment of ACL injuries. These results will be the first step toward early patient identification regarding treatment decisions. This is urgently needed to avoid (1) delayed surgeries and prolonged rehabilitation and (2) unnecessary surgeries. TRIAL REGISTRATION: this trial was registered on ClinicalTrials.gov (NCT05747079) on 10/02/2023.

Fatigue-induced Landing Alterations in ACL Reconstructed Athletes after Return-to-Sport.

At the time of return-to-sport, anterior cruciate ligament reconstructed athletes still show altered neuromechanics in their injured leg during single leg hopping tasks. Part of these alterations can be magnified when these athletes are fatigued. So far, little is known whether fatigue-induced landing alterations persist after return-to-sport. Therefore, the aim of this study was to evaluate whether these alterations persist in the six months following return-to-sport. Sixteen anterior cruciate ligament reconstructed athletes performed five unilateral hop tasks before and after a fatigue protocol. The hop tasks were executed at three different time points (return-to-sport, 3 and 6 months post-return-to-sport). A 2-by-3 repeated measures ANOVA was performed to evaluate whether fatigue-induced landing alterations persisted 3 and 6 months following return-to-sport. At 6 months following return-to-sport, fatigue still induces a reduction in hamstring medialis activation and an increase in the knee abduction moment during a vertical hop with 90-degree inward rotation. Most fatigue-induced landing alterations present at the time of return-to-sport normalize after resumption of sports activities. However, a larger knee abduction moment in the injured leg after resumption of sports activities can still be observed.

Postural balance strategies during landing at the moment of return-to-sports after anterior cruciate ligament reconstruction.

Most athletes that return to sport (RTS) after Anterior Cruciate Ligament (ACL) injury undergo reconstruction (ACLR) to restore their knee stability. The major concern for RTS is for the patient to be able to perform challenging dynamic tasks whilst adequately stabilizing the knee joint and maintaining their postural balance. Nevertheless, the interaction between knee protective mechanisms (such as knee unloading and knee stabilisation) and postural balance strategies has not yet been comprehensively analyzed. Thus, the aim of this study was to investigate landing balance strategies in ACLR athletes at time of RTS. Twenty-one athletes with a unilateral ACLR were tested at the time of RTS while performing a single leg hop for distance on both limbs. Three balance mechanisms that influence the GRF during the landing phase (foot placement, center of pressure (CoP) excursion, counter-rotation of segments) were investigated and compared between the ACL injured and uninjured limb. Interactions between knee protective mechanisms and postural balance strategies were tested using a statistical parametric mapping regression analysis. Results show that CoP excursions in the injured limb increased, as well as ankle joint moment contribution to anterior-posterior (A-P) GRF. Besides, patients presenting reduced knee joint contribution to A-P GRF had to compensate with higher hip joint contribution in order to maintain postural balance. In conclusion, ACLR athletes who at RTS still protect their reconstructed knee are forced to employ compensatory postural balance strategies. Therefore, there is a persistent trade-off between knee protection and postural balance at the moment of RTS.

Push-Off Dynamics Reveal Task-Independent Alterations in Athletes Returning to Sport after ACL Reconstruction.

PURPOSE: Athletes with an anterior cruciate ligament (ACL) reconstruction (ACLR) show persisting biomechanical and neuromuscular landing alterations. So far, most research focused on the landing phase of dynamic tasks where most ACL injuries occur. This study will assess whether these landing alterations are also present in the propulsion phase, in an attempt to identify generalized movement alterations. METHODS: Twenty-one athletes with ACLR (cleared by their surgeon and/or physiotherapist for return-to-sport) and twenty-one controls performed five single-leg hop tasks. Propulsion kinematics, kinetics, and muscle activations were compared between legs and between groups. RESULTS: Increased hamstrings activation was found during propulsion when comparing the ACLR limb with both the uninjured limb and the controls. In addition, decreased internal knee extension moments were found in the ACLR limb compared with the uninjured limb. CONCLUSIONS: Athletes with ACLR show task-independent alterations that unload the knee during the propulsion phase of single-leg hopping tasks. If longitudinal data deem these alterations to be maladaptive, more emphasis must be placed on their normalization during the propulsion phase, assuming beneficial carryover effects into the landing phase. Normalizing these patterns during rehabilitation may potentially reduce the risk of long-term complications such as reinjuries and posttraumatic osteoarthritis.

Effects of integrative neuromuscular training on the gait biomechanics of children with overweight and obesity.

OBJECTIVE: To analyze whether 13 weeks of integrative neuromuscular training can benefit spatiotemporal and kinematic parameters of gait in children with overweight/obesity. METHODS: This is a non-randomized controlled trial. Fifty children (10.77 ± 1.24 years, 31 girls) with overweight/obesity were allocated to an exercise group (EG) (n = 25) that carried out a 13-week exercise program based on fundamental movement skills, strength activities and aerobic training, and a control group (CG) (n = 25) that followed their normal lifestyle. Spatiotemporal (i.e., cadence, stance and support times, step length, and stride width) and kinematic (i.e., hip, pelvis, knee, and ankle angles) parameters were evaluated under laboratory conditions through a 3D analysis. ANCOVA was used to test raw and z-score differences between the EG and CG at post-exercise, adjusting for pre-exercise values. RESULTS: The EG maintained their baseline stance and single-limb support times while the CG increased them during walking (groups' difference: 3.1 and 1.9 centiseconds). The EG maintained baseline maximum foot abduction angle during the stance phase whereas the CG showed an increase (groups' difference: 3.9º). Additional analyses on kinematic profiles demonstrated that the EG walked with similar pelvic tilt and ankle abduction angles at post-exercise, while the CG increased the pelvic anterior tilt in the whole stance phase (mean groups' difference: 7.7º) and the ankle abduction angles in early- and mid-stance phases (mean groups' difference: 4.6º). No changes were observed in the rest of spatiotemporal and kinematic parameters. CONCLUSIONS: The integrative neuromuscular training stopped the progression of some biomechanical alterations during walking in children with overweight/obesity. These findings could contribute to preventing common movement-derived musculoskeletal disorders in this population, as well as preserving an optimal mechanical efficiency during walking.

Pilot study to investigate the feasibility of conducting a randomised controlled trial that compares Immediate versus Optional Delayed surgical repair for treatment of acute Anterior cruciate ligament injury: IODA pilot trial.

INTRODUCTION: Standard care for anterior cruciate ligament (ACL) injuries includes surgical reconstruction of the ACL. However, two randomised controlled trials (RCTs) concluded that conservative treatment does not result in inferior clinical outcomes compared with immediate ACL reconstruction. More research is needed to in the first place verify these results, and second to assess whether patient-specific parameters determine whether a patient would benefit from one treatment option over the other. However, before running a full RCT, it seems necessary to perform a pilot study that assesses the feasibility of recruiting patients with ACL for such a RCT. This is because recruitment may be challenging as many patients have strong treatment beliefs. Therefore, this pilot study will assess whether a large RCT is feasible with regard to participant recruitment, adherence to the allocated treatment arm and protocol feasibility. These pilot findings will help deciding about progressing to a future full RCT. METHODS AND ANALYSIS: This is a pragmatic, multicentre, randomised controlled pilot trial with two parallel groups. Patients with an acute ACL injury will be recruited from two Belgian hospitals. Patients will be randomised to either conservative treatment or surgical treatment. Patients will be followed-up at 3, 6 and 12 months postrandomisation. Recruitment feasibility will be evaluated by calculating the recruitment rate 4 months after the two sites have been initiated. Clear criteria for progression to a full trial are defined. Adherence to the protocol will be assessed by calculating the proportion of patients who complete the assessments. Furthermore the proportion of patients who cross-over between treatment arms during the follow-up period will be assessed. ETHICS AND DISSEMINATION: The study was approved by the ethical committees: Ethische Commissie Onderzoek UZ/KU Leuven (S62004) and Comité d'Ethique Hospitalo-Facultaire Universitaire de Liège (2020212). Results will be made available to caregivers, researchers and funder. TRIAL REGISTRATION NUMBER: This trial is registered on ClinicalTrials.gov (NCT04408690) on 29 May 2020.

Neuromuscular and biomechanical landing alterations persist in athletes returning to sport after anterior cruciate ligament reconstruction.

BACKGROUND: Anterior cruciate ligament reconstructed (ACLR) athletes show increased hamstrings activation and decreased knee flexion moments (KFMs) during single leg landing tasks at time of return-to-sport (RTS). Although these landing alterations seem protective in the short term, they might become undesirable if they persist after RTS. Therefore, the main aim of this study was to investigate whether those landing alterations persist in the months following RTS. METHODS: Sixteen athletes who had an ACLR performed five unilateral landing tasks at three different time points (at RTS, and at 3 and 6 months after RTS) while KFMs and hamstrings activation were recorded. The following clinical parameters were registered: isokinetic strength of quadriceps and hamstrings, ACL return-to-sport after injury scale (ACL-RSI), Tampa scale of kinesiophobia, self-reported instability and single leg hop distance. A one-way repeated measures analysis of variance (ANOVA) was used to assess whether landing deficits changed over time. Additionally, an explorative analysis was performed to assess whether those athletes whose deficits persisted the most could be identified based on baseline clinical parameters. RESULTS: The ANOVA showed no differences in landing deficits between sessions, indicating persisting reduced KFMs and increased hamstrings activation in the injured leg compared with the contralateral leg. A significant improvement of the quadriceps concentric strength (at 120°/s), ACL-RSI score and jump distance of the single leg hop was found over time. CONCLUSIONS: Landing alterations were not resolved 6 months after RTS. Additional interventions may be needed to normalize landing alterations prior to return to sport.

Athletes with an ACL reconstruction show a different neuromuscular response to environmental challenges compared to uninjured athletes.

BACKGROUND: Evidence suggests that neuromuscular alterations in patients with an anterior cruciate ligament reconstruction (ACLR) are rooted in neurocognitive and proprioceptive deficits. The aim of this study was to assess neuromuscular control of athletes with ACLR under increased cognitive and environmental challenges. RESEARCH QUESTION: Do athletes with ACLR show a different neuromuscular response to cognitive and environmental challenges relative to controls? METHODS: Cross-sectional study. Twenty athletes who had an ACLR (age: 23.7 ±â€¯4.3 years, 14 males, time post-surgery: 258.6 ±â€¯54 days) and twenty uninjured controls (age: 21.4 ±â€¯1.5 years, 14 males) performed a stepping down-task in four environmental conditions: no additional challenges, while performing a cognitive dual-task, while undergoing an unpredictable support surface perturbation, and with the cognitive dual-task and unpredictable perturbation combined. Muscle activations of the vastus medialis (VM), vastus lateralis, hamstrings medialis (HM), hamstrings lateralis (HL), gastrocnemius medialis, gastrocnemius lateralis (GL) and gluteus medius were recorded with surface EMG. A three-way ANOVA with main effects for group, dual-task and perturbation was used to compare muscle activations. RESULTS: Athletes with ACLR show larger HM (ES = 0.45) and HL activation (ES = 1.32) and lower VM activation (ES = 0.72), compared to controls. Athletes with ACLR show a significantly smaller increase in VM (ES = 0.69), VL (ES = 0.53) and GL activation (ES = 0.52) between perturbed and unperturbed tasks compared to controls. Furthermore, under cognitive loading a significantly larger decrease in HM activation (ES = 0.40) and (medial) co-contraction (ES = 0.75) was found in athletes with ACLR compared to controls. SIGNIFICANCE: Athletes with ACLR show an altered neuromuscular response which might represent an arthrogenic muscle response. They show less additional adaptation to perturbed tasks compared to controls, potentially as result of altered proprioceptive input. Furthermore a larger influence of increased cognitive loading on the neuromuscular control was found in athletes with ACLR, indicating that also neurocognitive limitations may contribute to altered neuromuscular control.

Single-Joint and Whole-Body Movement Changes in Anterior Cruciate Ligament Athletes Returning to Sport.

INTRODUCTION: Athletes returning to sport after anterior cruciate ligament reconstruction (ACLR) demonstrate prolonged changes in landing kinematics, kinetics, and muscle activation, predisposing them for reinjury, knee osteoarthritis, and/or knee instability. So far, researchers have been focusing on how kinematics and kinetics change in every joint separately. However, as the human body operates within a kinetic chain, we will assess whether single-joint changes are associated with whole-body changes. METHODS: Twenty-one athletes who had an ACLR and 21 uninjured controls performed five unilateral landing tasks, whereas lower limb kinematics, kinetics, and muscle activations of vastus medialis, vastus lateralis, biceps femoris, semitendinosus, semimembranosus, gastrocnemius, and gluteus medius were recorded. Single-joint landing kinematics, kinetics, and muscle activations of the ACL-injured leg were compared with the uninjured leg and compared with the control group. Whole-body changes were assessed by decomposing movements into fundamental components using marker-based principal component analysis (PCA). RESULTS: We found several single-joint changes in landing kinematics, kinetics, and muscle activations in the athletes with ACLR that were seen across all tasks and therefore of major interest as they are likely to occur during sports as well. Hamstrings activation increased and external knee flexion moments decreased in the ACL-injured leg compared with their uninjured leg. Furthermore, hip adduction moments and knee abduction angles decreased compared with the control group. The PCA could detect changes in whole-body movement, which were task-specific. CONCLUSIONS: Athletes with ACLR still show protective task-independent single-joint kinematic, kinetic, and muscle activation changes during single-leg landings at the time of return to sport. These single-joint changes were not consistently accompanied by changes in whole-body movements (revealed by marker-based PCA). Whole-body expressions of the single-joint compensations are likely to be affected by the demands of the task.

Are Anterior Cruciate Ligament-reconstructed Athletes More Vulnerable to Fatigue than Uninjured Athletes?

INTRODUCTION: Fatigue has a negative impact on lower extremity neuromuscular and biomechanical control. Because anterior cruciate ligament reconstruction (ACLR) athletes show already neuromuscular/biomechanical deficits in an unfatigued state, the negative impact of fatigue may magnify these deficits or help expose other deficits. So far, this has only scarcely been assessed warranting further research. METHODS: Twenty-one athletes who had an ACLR and 21 uninjured controls performed five unilateral landing tasks before and after a match simulation protocol, whereas muscle activation (vastus medialis, vastus lateralis, hamstrings medialis, hamstrings lateralis, gastrocnemius medialis, gastrocnemius lateralis, gluteus medius) and landing kinematics and kinetics of the hip, knee, and ankle joint were recorded. A two-way ANOVA with a mixed-model design (main effects for group and fatigue) was used to compare landing kinematics, kinetics, and muscle activation between groups, and prefatigue and postfatigue. To avoid unjustified reduction of the data to discrete values, we used one-dimensional Statistical Parametric Mapping. RESULTS: Only two interaction effects were found: an increased postfatigue knee abduction moment and an increased postfatigue thorax flexion angle was found in the ACL injured legs but not in the uninjured legs of the ACL group or in the control group, during the lateral hop and the vertical hop with 90° medial rotation, respectively. CONCLUSIONS: This study showed that overall ACLR athletes and uninjured athletes have similar biomechanical and neuromuscular responses to fatigue. For two biomechanical parameters, however, we did find an interaction effect, suggesting that landing deficits in ACLR athletes may become clearer in certain tasks when fatigued.

Match Play-induced Changes in Landing Biomechanics with Special Focus on Fatigability.

INTRODUCTION: Growing evidence exists that match-related fatigue induces biomechanical alterations that might increase lower extremity injury risk. Fatigue studies often use match simulation protocols that expose all subjects to a standardized demand (e.g., a fixed distance/time). In those studies, the induced level of fatigue depends then on subjects' fatigability. If between-subject variability in fatigability is high, this might confound overall fatigue effects. Therefore, the first aim was to investigate whether a fatigue protocol with fixed demand causes alterations in landing patterns. Second, we assessed the relationship between fatigability and landing patterns as we hypothesized that athletes with high fatigability would show movement patterns that involve greater injury risk. METHODS: Eighteen athletes performed three different unilateral landing tasks before and after a match simulation protocol while muscle activation (vastus medialis, vastus lateralis, hamstrings medialis, hamstrings lateralis, gastrocnemius medialis, gastrocnemius lateralis, and gluteus medius) and landing kinematics and kinetics of the hip, knee, and ankle joint were recorded. Furthermore, RPE was administered to measure fatigability. ANOVA analyses were conducted to investigate fatigue effects on landing patterns. Correlation analyses assessed the relationship between fatigability (postfatigue RPE) and landing patterns. RESULTS: The ANOVA analyses did not show any overall postfatigue alterations in landing patterns. However, correlation analyses showed an association between fatigability and landing patterns. Athletes who had higher RPE scores showed smaller postfatigue knee flexion angles and smaller pre- and postfatigue knee abduction angles across different landing tasks. CONCLUSION: The fixed demand protocol did not cause overall alterations in landing patterns. When fatigability was taken into account, high fatigability was related with less optimal landing patterns.

Is knee neuromuscular activity related to anterior cruciate ligament injury risk? A pilot study.

BACKGROUND: There is limited evidence on neuromuscular risk factors for anterior cruciate ligament (ACL) injuries, with most work mainly focusing on hamstrings and quadriceps muscle strength. This prospective pilot study explored if neuromuscular activation patterns of the quadriceps and hamstrings during a drop vertical jump influence ACL injury risk. METHODS: Forty-six female athletes performed a drop vertical jump at baseline. Injuries were monitored throughout a one-year follow-up. Neuromuscular activation patterns of the vastus medialis, vastus lateralis, hamstrings medialis and hamstrings lateralis, and selected landing kinematic and kinetic profiles (knee flexion, knee abduction and hip flexion angles, and knee abduction moments), were compared between athletes who sustained a non-contact ACL injury and those who remained injury free. Electromyogram vector fields were created to represent neuromuscular activation patterns of muscle pairs around the knee joint rather than only considering individual muscle activations, and compared using Statistical Parametric Mapping. RESULTS: Four athletes sustained an ACL injury. Significantly greater {hamstrings medials, hamstrings lateralis}, {vastus lateralis, hamstrings lateralis} and {hamstrings lateralis, vastus medialis} activations, mainly due to greater hamstrings lateralis activation, were found in the injured group around peak loading and just before take-off (P < 0.001). No group differences were found in knee flexion, knee abduction and hip flexion angles, or knee abduction moments. CONCLUSIONS: This pilot study revealed initial evidence that athletes already showed altered neuromuscular activation patterns prior to sustaining an ACL injury, namely increased lateral and posterior muscle activations.

Knee and Hip Joint Kinematics Predict Quadriceps and Hamstrings Neuromuscular Activation Patterns in Drop Jump Landings.

PURPOSE: The purpose was to assess if variation in sagittal plane landing kinematics is associated with variation in neuromuscular activation patterns of the quadriceps-hamstrings muscle groups during drop vertical jumps (DVJ). METHODS: Fifty female athletes performed three DVJ. The relationship between peak knee and hip flexion angles and the amplitude of four EMG vectors was investigated with trajectory-level canonical correlation analyses over the entire time period of the landing phase. EMG vectors consisted of the {vastus medialis(VM),vastus lateralis(VL)}, {vastus medialis(VM),hamstring medialis(HM)}, {hamstring medialis(HM),hamstring lateralis(HL)} and the {vastus lateralis(VL),hamstring lateralis(HL)}. To estimate the contribution of each individual muscle, linear regressions were also conducted using one-dimensional statistical parametric mapping. RESULTS: The peak knee flexion angle was significantly positively associated with the amplitudes of the {VM,HM} and {HM,HL} during the preparatory and initial contact phase and with the {VL,HL} vector during the peak loading phase (p<0.05). Small peak knee flexion angles were significantly associated with higher HM amplitudes during the preparatory and initial contact phase (p<0.001). The amplitudes of the {VM,VL} and {VL,HL} were significantly positively associated with the peak hip flexion angle during the peak loading phase (p<0.05). Small peak hip flexion angles were significantly associated with higher VL amplitudes during the peak loading phase (p = 0.001). Higher external knee abduction and flexion moments were found in participants landing with less flexed knee and hip joints (p<0.001). CONCLUSION: This study demonstrated clear associations between neuromuscular activation patterns and landing kinematics in the sagittal plane during specific parts of the landing. These findings have indicated that an erect landing pattern, characterized by less hip and knee flexion, was significantly associated with an increased medial and posterior neuromuscular activation (dominant hamstrings medialis activity) during the preparatory and initial contact phase and an increased lateral neuromuscular activation (dominant vastus lateralis activity) during the peak loading phase.

Dynamic Neuromuscular Control of the Lower Limbs in Response to Unexpected Single-Planar versus Multi-Planar Support Perturbations in Young, Active Adults.

PURPOSE: An anterior cruciate ligament (ACL) injury involves a multi-planar injury mechanism. Nevertheless, unexpected multi-planar perturbations have not been used to screen athletes in the context of ACL injury prevention yet could reveal those more at risk. The objective of this study was to compare neuromuscular responses to multi-planar (MPP) and single-planar perturbations (SPP) during a stepping-down task. These results might serve as a basis for future implementation of external perturbations in ACL injury screening programs. METHODS: Thirteen young adults performed a single leg stepping-down task in eight conditions (four MPP and four SPP with a specified amplitude and velocity). The amplitudes of vastus lateralis (VL), vastus medialis (VM), hamstrings lateralis (HL), hamstrings medialis (HM) EMG activity, medio-lateral and anterior-posterior centre of mass (COM) displacements, the peak knee flexion and abduction angles were compared between conditions using an one-way ANOVA. Number of stepping responses were monitored during all conditions. RESULTS: Significantly greater muscle activity levels were found in response to the more challenging MPP and SPP compared to the less challenging conditions (p < 0.05). No differences in neuromuscular activity were found between the MPP conditions and their equivalents in the SPP. Eighteen stepping responses were monitored in the SPP versus nine in the MPP indicating that the overall neuromuscular control was even more challenged during the SPP which was supported by greater COM displacements in the SPP. CONCLUSION: The more intense MPP and SPP evoked different neuromuscular responses resulting in greater muscle activity levels compared to small perturbations. Based on the results of COM displacements and based on the amount of stepping responses, dynamic neuromuscular control of the knee joint appeared less challenged during the MPP. Therefore, future work should investigate extensively if other neuromuscular differences (i.e. co-activation patterns and kinetics) exist between MPP and SPP. In addition, future work should examine the influence on the neuromuscular control of the magnitude of the perturbations and the magnitude of stepping height and stepping distance.