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1.
Bull Exp Biol Med ; 139(2): 235-7, 2005 Feb.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-16027816

RESUMO

We studied local expression of insulin-like growth factor 1, insulin-like growth factor receptor, epithelial growth factor, transforming growth factor beta2, PCNA, TNF-alpha, type I TNF receptor, Fas, FasL, IFN-gamma, IL-1beta, IL-4, IL-6, IL-8, IL-10, and IL-12 genes in intact and hyperplastic endometrium. Endometrial hyperplasia was associated with reduced production of TNF-alpha (p<0.05), PCNA (p<0.05), and epithelial growth factor mRNA and enhanced production of Fas mRNA (p<0.01). The expression of TNF-R1, IL-1beta, and IL-12 genes decreased only in glandular cystic hyperplasia (p<0.05 for all genes), expression of insulin-like growth factor 1 gene decreased only in adenomatous hyperplasia (p<0.05). Dufaston therapy of glandular cystic hyperplasia and zoladex therapy of adenomatous hyperplasia normalized expression of Fas receptor, PCNA, and insulin-like growth factor 1 genes, while the expression of IFN-gamma and IL-6 genes, which was normal in hyperplasia, decreased (p<0.05). Zoladex therapy decreased the production of transforming growth factor beta2 (p<0.05) and IL-1beta (p<0.01) mRNA, dufaston therapy decreased production of TNF-alpha (p<0.05) and IL-4 mRNA (p<0.05). Hence, both apoptosis and proliferative activity were suppressed in endometrial hyperplasia, and hormone therapy created prerequisites for transition of the endometrium into the normal proliferation stage.


Assuntos
Citocinas/metabolismo , Didrogesterona/uso terapêutico , Hiperplasia Endometrial/tratamento farmacológico , Gosserrelina/uso terapêutico , Apoptose , Proliferação de Células , Células Cultivadas , Citocinas/genética , Hiperplasia Endometrial/genética , Hiperplasia Endometrial/metabolismo , Feminino , Expressão Gênica , Humanos , RNA Mensageiro/análise , RNA Mensageiro/metabolismo
2.
Klin Med (Mosk) ; 83(5): 42-5, 2005.
Artigo em Russo | MEDLINE | ID: mdl-15984582

RESUMO

The purpose of the study was to establish the prevalence of uric acid (UA) metabolism disturbances as a possible risk factor of urate nephropathy in women of various age groups. The authors carried out a retrospective analysis of 757 case histories and performed uricemia and uricosuria screening in women aged 18 to 69 years. The study revealed significant age-dependent elevation of uricemia, with hyperuricemia (HUE) at the age of 60 to 69 years old. The study also found age-dependent increase of HUE rate with its significant elevation in postmenopausal women (older than 50 years), compared with HUE rate in reproductive age women (18 to 49 years old) -37.9% vs. 11.4%. For the first time the researchers established UA excretion level and found a significant tendency of uricosuria to decrease with age (p < 0.016 between the groups of 40 to 49 and 50 to 59 years old). The highest rate of hyperuricosuria was revealed in women of 40 to 49 years old (22.2%), while in women of 18 to 29 and 60 to 69 years old it was 10.1% to 12.1%. For the first time the authors established the rate of hypouricosuria in women, which culminated in women older than 50 (22% of cases). The increase of HUE rate, which is most prominent in postmenopausal women, is associated with the decrease in UA excretion, accompanied by the decrease of hyperuricosuria rate and increase of hypouricosuria rate. Taking into account high prevalence of UA metabolism disturbances in women older than 50, menopause may be considered a risk factor of HUE and urate nephropathy.


Assuntos
Menopausa/metabolismo , Ácido Úrico/sangue , Ácido Úrico/urina , Adolescente , Adulto , Idoso , Ritmo Circadiano/fisiologia , Feminino , Humanos , Hiperuricemia/complicações , Hiperuricemia/epidemiologia , Hiperuricemia/metabolismo , Nefropatias/epidemiologia , Nefropatias/etiologia , Nefropatias/metabolismo , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Fatores de Risco , Federação Russa/epidemiologia
3.
Ter Arkh ; 76(11): 88-93, 2004.
Artigo em Russo | MEDLINE | ID: mdl-15658548

RESUMO

AIM: To investigate efficacy, tolerance and safety of the drug vitrum osteomag one tablet of which contains 600 mg calcium (1500 mg calcium carbonate), 200 IU of cholecalcepherol, 40 mg of magnesium, zinc (7.5 mg), copper (1 mg), manganese (1.8 mg) and boron (250 mcg) in women with osteopenia for prevention of osteoporosis. MATERIAL AND METHODS: A multicenter comparative open trial of vitrum osteomag influence on mineral bone density (MBD), change of pain syndrome in bones, index of calcium-phosphorous metabolism covered 334 postmenopausal women with osteopenia. MBD was measured in low-back spine and proximal part of the hip with DEXA method. All the patients were divided into 3 groups: 125 women taking 2 tablets of vitrum osteomag daily for 12 months (group 1); 111 women taking 1500 mg calcium carbonate (group 2); 96 women--control group (only observation). RESULTS: Vitrum osteomag relieved pain in the back and joints, had a positive effect on bone density (+1.5%) and proximal parts of the hip (0.6-0.93%) exceeding the effect of calcium carbonate only which preserves the initial MBD in low back spine but does not prevent bone loss in the hip. MBD dynamics in patients given vitrum osteomag differs essentially from one in the control group (from -1.9 to -2.91%) which demonstrates a reliable preventive anti-osteoporotic effect of this medication. The drug increases the level of general and ionized calcium in blood but does not cause hypercalcemia lowering the level of parathormone in blood. The rate of side effects in group 1 was 14.4% and did not differ much from that in group 2 (16.2%). CONCLUSION: The results of the study allow to recommend vitrum osteomag for prophylaxis of a rapid loss of bone tissue mineral density.


Assuntos
Suplementos Nutricionais , Osteoporose Pós-Menopausa/prevenção & controle , Absorciometria de Fóton , Idoso , Densidade Óssea/efeitos dos fármacos , Cálcio/sangue , Carbonato de Cálcio/administração & dosagem , Colecalciferol/administração & dosagem , Feminino , Fêmur/diagnóstico por imagem , Fêmur/efeitos dos fármacos , Humanos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/efeitos dos fármacos , Magnésio/administração & dosagem , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/diagnóstico por imagem , Osteoporose Pós-Menopausa/tratamento farmacológico , Hormônio Paratireóideo/sangue , Oligoelementos/administração & dosagem
4.
Bull Exp Biol Med ; 136(3): 270-2, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15098542

RESUMO

Correlations between local expression of insulin-like growth factor 1, insulin-like growth factor receptor, epithelial growth factor, transforming growth beta2 factor, PCNA, TNF-alpha, TNF receptor 1, Fas, FasL, IFN-gamma, IL-1beta, IL-4, IL-6, IL-8, IL-10, and IL-12 genes in intact and hyperplastic endometrium and in the endometrium after hormone therapy were analyzed. Numerous correlations at the proliferation and secretion stages of the menstrual cycle indicate balanced cytokine system. The number of correlations decreases in glandular cystic and more so in atypical hyperplasia, indicating imbalance in the cytokine system. Dufastone and zoladex therapy did not lead to recovery of this balance, but higher correlations between the expression of some factors of cell proliferation attest to the beginning of normalization of pathologically changed endometrium.


Assuntos
Citocinas/biossíntese , Hiperplasia Endometrial/patologia , Endométrio/patologia , Antineoplásicos Hormonais/farmacologia , Apoptose , Divisão Celular , Citocinas/metabolismo , Desoxirribonucleases/metabolismo , Endométrio/efeitos dos fármacos , Endométrio/metabolismo , Fator de Crescimento Epidérmico/metabolismo , Feminino , Gosserrelina/farmacologia , Humanos , Fator de Crescimento Insulin-Like I/metabolismo , Ciclo Menstrual , Antígeno Nuclear de Célula em Proliferação/metabolismo , RNA/metabolismo , RNA Mensageiro/metabolismo , Receptor IGF Tipo 1/metabolismo , Reação em Cadeia da Polimerase Via Transcriptase Reversa
5.
Ter Arkh ; 73(10): 33-8, 2001.
Artigo em Russo | MEDLINE | ID: mdl-11763512

RESUMO

AIM: To study hemodynamic effects of replacement hormone therapy (RHT) with trisecvens, beta-blocker betaksolol and their combination in perimenopausal and menopausal women with hypertension. MATERIAL AND METHODS: The study was made of 60 menopausal women aged 45-60 with mild and moderate arterial hypertension (AH). The women had no contraindications to either RHT or beta-blockers. They were randomized into three groups: group 1 received trisekvens, group 2--trisekvens plus betaksolol in a dose 10-20 mg/day, group 3--betaksolol. Arterial pressure (AP) and heart rate (HR) were measured before the treatment, in one month and each three months for a year. ECG and echo-CG were registered before treatment and each 3 months of the therapy. AP monitoring covered 50% of the patients of each group before the treatment and after 1 and 3 months of it. The data were analysed according to SAS system. RESULTS: Group 1 patients showed no significant changes in AP and HR. Group 2 and 3 patients' AP lowered, in group 2 the fall of systolic AP being more pronounced. 12-month therapy brought about a 10.3% decrease in left ventricular myocardial mass index in group 2. CONCLUSION: RHT with trisekvens in combination with beta-blocker in long-term use potentiates the effect on systolic AP and reduced hypertrophy of the left ventricle. RHT does not produce a significant effect on AP in women with AH recorded before the menopause.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Anti-Hipertensivos/uso terapêutico , Betaxolol/uso terapêutico , Climatério , Estradiol/uso terapêutico , Estriol/uso terapêutico , Terapia de Reposição de Estrogênios , Hemodinâmica , Hipertensão/tratamento farmacológico , Noretindrona/análogos & derivados , Noretindrona/uso terapêutico , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Hipertensão/fisiopatologia , Pessoa de Meia-Idade , Pós-Menopausa
8.
Ter Arkh ; 70(10): 33-7, 1998.
Artigo em Russo | MEDLINE | ID: mdl-9864801

RESUMO

AIM: To examine postmenopausal women free of organic cardiovascular lesions receiving replacement hormonotherapy (RHT) for ECG abnormalities, control of the detected cardiovascular defects. MATERIALS AND METHODS: ECG was conducted in 61 postmenopausal women before and during RHT with climen and climonorm. RESULTS: ECG registers frequent functional abnormalities in postmenopausal women. A 3-month RHT improved the patients' condition. ECG parameters improved on RHT month 9. CONCLUSION: RHT of postmenopausal women corrects general condition of such patients as well as functional ECG parameters.


Assuntos
Eletrocardiografia/efeitos dos fármacos , Terapia de Reposição Hormonal , Pós-Menopausa/fisiologia , Antagonistas de Androgênios/uso terapêutico , Doenças Cardiovasculares/prevenção & controle , Acetato de Ciproterona/uso terapêutico , Combinação de Medicamentos , Quimioterapia Combinada , Estradiol/análogos & derivados , Estradiol/uso terapêutico , Estrogênios Conjugados (USP)/uso terapêutico , Feminino , Seguimentos , Humanos , Levanogestrel/uso terapêutico , Pessoa de Meia-Idade , Pós-Menopausa/efeitos dos fármacos , Congêneres da Progesterona/uso terapêutico
11.
Vestn Ross Akad Med Nauk ; (2): 34-8, 1997.
Artigo em Russo | MEDLINE | ID: mdl-9376728

RESUMO

With age-specific diminished and excluded ovarian function and estrogen deficiency, 60% of females may develop various systemic disorders (the menopausal syndrome, urogenital and cardiovascular diseases, osteoporosis). In the past 10-15 years, hormone replacement treatment regimens have been developed for climacteric females. Numerous epidemiological surveys have indicated that hormone replacement therapy shows a 50% reduction in the incidence of stroke, myocardial infarction, bone fractures. Therefore, post-menopausal hormone therapy is indicated both for therapeutical and prophylactic purposes, which may increase female longevity.


Assuntos
Climatério , Terapia de Reposição de Estrogênios , Idoso , Idoso de 80 Anos ou mais , Doenças Cardiovasculares/prevenção & controle , Climatério/fisiologia , Estradiol/análogos & derivados , Estradiol/uso terapêutico , Estriol/análogos & derivados , Estriol/uso terapêutico , Estrogênios Conjugados (USP)/uso terapêutico , Feminino , Doenças Urogenitais Femininas/prevenção & controle , Humanos , Expectativa de Vida , Pessoa de Meia-Idade , Osteoporose/prevenção & controle , Progestinas/uso terapêutico
14.
Akush Ginekol (Mosk) ; (6): 29-34, 1995.
Artigo em Russo | MEDLINE | ID: mdl-8779350

RESUMO

Comprehensive clinicophysiological examinations of 80 patients suffering from the intermenstrual pain syndrome revealed organic changes in the pelvic organs of 92.5% of women and disturbances in the central structures participating in the conduction and control of pain sensitivity and vasomotor regulation in all the examinees, these changes correlating with specific vegetovascular and psychoemotional disorders. Three pathogenetic variants of development of this syndrome were defined.


Assuntos
Síndrome Pré-Menstrual/patologia , Adulto , Temperatura Baixa , Diagnóstico Diferencial , Feminino , Humanos , Ciclo Menstrual/sangue , Ciclo Menstrual/psicologia , Pessoa de Meia-Idade , Limiar da Dor , Síndrome Pré-Menstrual/sangue , Síndrome Pré-Menstrual/diagnóstico , Síndrome Pré-Menstrual/etiologia , Síndrome Pré-Menstrual/psicologia , Psicofisiologia
16.
Akush Ginekol (Mosk) ; (3): 41-4, 1995.
Artigo em Russo | MEDLINE | ID: mdl-7653729

RESUMO

Eighty-eight women subjected to total oophorectomy for benign tumors and tumor-like formations in the uterus and tubes were examined. The mean age of the patients was 33.3 +/- 2.4 years. Bone tissue status was assessed by monophoton absorptiometry and computer-aided tomography. A negligible reduction of mineral density of osseous tissue was observed early after oophorectomy, its annual loss being high. In later periods after surgery, vice versa, a more expressed reduction of bone density and a relatively low rate of its annual reduction were observed. Specific features of the processes of osteoporosis in various periods after surgical removal of the ovaries make substitution hormonal therapy advisable for oophorectomized patients in the early periods after surgery, in order to effectively prevent and treat osteoporosis.


Assuntos
Densidade Óssea , Osteoporose/etiologia , Ovariectomia/efeitos adversos , Absorciometria de Fóton , Adulto , Osso e Ossos/diagnóstico por imagem , Interpretação Estatística de Dados , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Osteoporose/diagnóstico , Osteoporose/diagnóstico por imagem , Fatores de Tempo , Tomografia Computadorizada por Raios X
18.
Akush Ginekol (Mosk) ; (5): 24-8, 1993.
Artigo em Russo | MEDLINE | ID: mdl-8250132

RESUMO

Functional status of the central and autonomic nervous system was analyzed in 28 patients with the premenstrual syndrome one of whose manifestations was disordered thermoregulation. The examinations were carried out during both cycle phases. Analysis of the EEG data and clinical findings has shown different patterns of autonomic thermoregulation disturbances in three groups of patients and permitted the authors to suggest that changed activity of certain neurotransmitter systems connected with hormonal secretion over the course of the cycle was responsible for these disturbances.


Assuntos
Febre/etiologia , Síndrome Pré-Menstrual/etiologia , Adolescente , Adulto , Sistema Nervoso Autônomo/fisiopatologia , Regulação da Temperatura Corporal/fisiologia , Eletrocardiografia , Eletroencefalografia , Feminino , Febre/fisiopatologia , Resposta Galvânica da Pele , Humanos , Ciclo Menstrual/fisiologia , Síndrome Pré-Menstrual/fisiopatologia
19.
Tsitol Genet ; 26(3): 56-62, 1992.
Artigo em Russo | MEDLINE | ID: mdl-1502734

RESUMO

Clinical-genetic examination of 50 patients with menopause praecox syndrome has been performed. The results of the examination show genetic syndrome heterogeneity. Chromosomal and gene mutations take part in the syndrome pathogenesis. Chromosomal abnormalities frequency is 12%. Chromosomal aberrations are presented by different mosaicism types of sex chromosomes. Monogenic syndrome genesis with different inheritance types of the pathologic gene is determined: autosomal-recessive or autosomal-dominant.


Assuntos
Insuficiência Ovariana Primária/genética , Adulto , Aberrações Cromossômicas/epidemiologia , Aberrações Cromossômicas/genética , Transtornos Cromossômicos , Feminino , Genes Dominantes/genética , Genes Recessivos/genética , Humanos , Mosaicismo/genética , Mutação/genética , Linhagem
20.
Akush Ginekol (Mosk) ; (2): 48-52, 1992 Feb.
Artigo em Russo | MEDLINE | ID: mdl-1282305

RESUMO

Brain hemodynamics was studied in 76 patients with oligomenorrhea aged 18 to 35 from the data of rheoencephalography. Disorders of the regional tone of brain vessels were different and related to the time of the menstrual cycle disorder; this may be explained by the degree of changes in various neuromediator mechanisms of brain circulation and reproductive system function regulation.


Assuntos
Encéfalo/irrigação sanguínea , Circulação Cerebrovascular/fisiologia , Oligomenorreia/fisiopatologia , Adolescente , Adulto , Isquemia Encefálica/diagnóstico , Isquemia Encefálica/etiologia , Feminino , Hemodinâmica/fisiologia , Humanos , Norepinefrina/fisiologia , Oligomenorreia/complicações , Pletismografia de Impedância , Serotonina/fisiologia , Substância P/fisiologia
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