[Pathological features of coronary heart disease in patient of elderly and senile age depending on a blood flow condition in the abdominal aorta].

AIM: To perform the analysis of correlation of clinical symptoms and laboratory sings in patients of elderly and senile age with coronary heart disease depending on a blood flow condition in the pool of abdominal aorta. MATERIAL AND METHODS: Longitudinal clinical research was conducted. The register was made by 132 patients of elderly and senile age with coronary heart disease being on treatment during the period since 2013-2014. RESULTS: Results of the research of correlation of clinical symptoms and indexes of lipidemia in patients of elderly and senile age with coronary heart disease depending on a blood flow condition in the pool of abdominal aorta are performed. CONCLUSION: Specific features of the cardiovascular pathology and a course of coronary heart disease in combination with atherosclerosis of the abdominal aorta and its visceral branches are revealed.

[Bacterial endotoxinemia and risk of hemorrhage from oesophageal varicose veins in patients with liver cirrhosis].

This work was designed to substantiate the necessity of estimating serum bacterial endotoxin levels in patients with liver cirrhosis (LC) for the prognostication of the risk of bleeding from oesophageal varices. The prospective cohort study included 90 patients with LC and clinical signs of portal hypertension. Total endotoxin of Gram-negative bacteria was measured by the activated particle method. The intensity of endotoxemia was estimated using the end-point turbidimetric test (variant of LAL test). Pronounced endotoxemia was associated with acute bleeding from oesophageal varices. Its severity in the patients with the history of hemorrhage was higher than in the absence of this complication. The endotoxin level in the range from 0 to 4 ng/ml suggested low probability of hemorrhage; its risk increased significantly at the endotoxin level in excess of 4.1 ng/ ml. It is concluded that the severity of endotoxemia in LC patients correlates with the degree of oesophageal vein dilation and hemorrhage, the endotoxin level of 4 ng/ml being a reliable diagnostic criterion for the associated risks.

[Clinical signs of endothelial disorders in patients with severe sepsis].

A clinical-experimental study was carried out. The objective was to find some regularities in endothelial disorder progression in patients with severe sepsis and to evaluate clinical efficacy of some methods of hepatic protection. Experimental part of work was carried out on 59 mice with induced peritonitis. Obtained data shows early emergence of lung disorders that precede changes in hepatic tissue. Clinical part of work included 181 patient with severe sepsis. It was noted that acute respiratory distress syndrome symptoms occurred earlier than hepatic dysfunction, if the latter joints, it aggravates the patients status and worsens the prognosis. Use of Heptral (Ademetionine) and Ketamine in order to protect liver is a clinically effective method which makes possible to decrease the lethality.

[The prognostic role of interleukin-6 in peritoneal exudate of patients with diffuse peritonitis].

A prospective longitudinal controlled investigation of 189 patients with secondary diffuse peritonitis was performed. A correlation between the levelof interleuikin-6 of peritoneal exudate, the severity of the patients' state, the number of complications and outcome of the course of the disease was established. The maximal number of complications and unfavorable outcomes falls on the peak value ofinterleuikin-6.

Effect of ceruloplasmin on the number and resistance of erythrocytes during acute physical exercise.

Acute physical exercise was followed by a decrease in the osmotic resistance of erythrocytes, shortening of the time-to-onset of erythrocyte hemolysis, and increase in the sorption capacity of the cell membrane. Administration of ceruloplasmin 24 h before physical exercise normalizes membrane resistance in red blood cells.